The Role of Tumor-Infiltrating B Cells in Tumor Immunity

The Role of Tumor-Infiltrating B Cells in Tumor Immunity

Earlier studies on elucidating the role of lymphocytes in tumor immunity predominantly focused on T cells. However, the role of B cells in tumor immunity has increasingly received better attention in recent studies. The B cells that infiltrate tumor tissues are called tumor-infiltrating B cells (TIB...

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Main Authors: Fei Fei Guo, Jiu Wei Cui
Format: Article
Language:English
Published: Hindawi Limited 2019-01-01
Series:Journal of Oncology
Online Access:http://dx.doi.org/10.1155/2019/2592419
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spelling doaj-14e12277646446c887dc78b05aabd28d2020-11-25T02:44:24ZengHindawi LimitedJournal of Oncology1687-84501687-84692019-01-01201910.1155/2019/25924192592419The Role of Tumor-Infiltrating B Cells in Tumor ImmunityFei Fei Guo0Jiu Wei Cui1Cancer Center, The First Hospital of Jilin University, Changchun 130021, ChinaCancer Center, The First Hospital of Jilin University, Changchun 130021, ChinaEarlier studies on elucidating the role of lymphocytes in tumor immunity predominantly focused on T cells. However, the role of B cells in tumor immunity has increasingly received better attention in recent studies. The B cells that infiltrate tumor tissues are called tumor-infiltrating B cells (TIBs). It is found that TIBs play a multifaceted dual role in regulating tumor immunity rather than just tumor inhibition or promotion. In this article, latest research advances focusing on the relationship between TIBs and tumor complexity are reviewed, and light is shed on some novel ideas for exploiting TIBs as a possible tumor biomarker and potential therapeutic target against tumors.http://dx.doi.org/10.1155/2019/2592419
collection DOAJ
language English
format Article
sources DOAJ
author Fei Fei Guo
Jiu Wei Cui
spellingShingle Fei Fei Guo
Jiu Wei Cui
The Role of Tumor-Infiltrating B Cells in Tumor Immunity
Journal of Oncology
author_facet Fei Fei Guo
Jiu Wei Cui
author_sort Fei Fei Guo
title The Role of Tumor-Infiltrating B Cells in Tumor Immunity
title_short The Role of Tumor-Infiltrating B Cells in Tumor Immunity
title_full The Role of Tumor-Infiltrating B Cells in Tumor Immunity
title_fullStr The Role of Tumor-Infiltrating B Cells in Tumor Immunity
title_full_unstemmed The Role of Tumor-Infiltrating B Cells in Tumor Immunity
title_sort role of tumor-infiltrating b cells in tumor immunity
publisher Hindawi Limited
series Journal of Oncology
issn 1687-8450
1687-8469
publishDate 2019-01-01
description Earlier studies on elucidating the role of lymphocytes in tumor immunity predominantly focused on T cells. However, the role of B cells in tumor immunity has increasingly received better attention in recent studies. The B cells that infiltrate tumor tissues are called tumor-infiltrating B cells (TIBs). It is found that TIBs play a multifaceted dual role in regulating tumor immunity rather than just tumor inhibition or promotion. In this article, latest research advances focusing on the relationship between TIBs and tumor complexity are reviewed, and light is shed on some novel ideas for exploiting TIBs as a possible tumor biomarker and potential therapeutic target against tumors.
url http://dx.doi.org/10.1155/2019/2592419
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