Serum and glucocorticoid inducible protein kinases (SGKs): a potential target for cancer intervention

Serum and glucocorticoid inducible protein kinases (SGKs): a potential target for cancer intervention

The serum and glucocorticoid inducible protein kinase (SGK) family members share similar structure, substrate specificity and function with AKT and signal downstream of the phosphatidylinositol 3-kinase (PI3K) signalling pathway. They regulate a range of fundamental cellular processes such as cell p...

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Main Authors: Rajesh Basnet, Grace Qun Gong, Chenyao Li, Ming-Wei Wang
Format: Article
Language:English
Published: Elsevier 2018-09-01
Series:Acta Pharmaceutica Sinica B
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383518302442
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spelling doaj-14e3d8be4e7c4fb0b87237ee11d8942b2020-11-24T22:47:58ZengElsevierActa Pharmaceutica Sinica B2211-38352018-09-0185767771Serum and glucocorticoid inducible protein kinases (SGKs): a potential target for cancer interventionRajesh Basnet0Grace Qun Gong1Chenyao Li2Ming-Wei Wang3The National Center for Drug Screening and the CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CAS), Shanghai 201203, China; University of Chinese Academy of Sciences, Beijing 100049, ChinaThe National Center for Drug Screening and the CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CAS), Shanghai 201203, China; Department of Molecular Medicine and Pathology, The University of Auckland, Auckland, New ZealandThe National Center for Drug Screening and the CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CAS), Shanghai 201203, China; University of Chinese Academy of Sciences, Beijing 100049, ChinaThe National Center for Drug Screening and the CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CAS), Shanghai 201203, China; University of Chinese Academy of Sciences, Beijing 100049, China; School of Pharmacy, Fudan University, Shanghai 201203, China; Corresponding author at: The National Center for Drug Screening and the CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CAS), Shanghai 201203, China.The serum and glucocorticoid inducible protein kinase (SGK) family members share similar structure, substrate specificity and function with AKT and signal downstream of the phosphatidylinositol 3-kinase (PI3K) signalling pathway. They regulate a range of fundamental cellular processes such as cell proliferation and survival, thereby playing an important role in cancer development. This perspective intends to give an overview on the involvement of SGKs (particularly SGK3) in cancer progression, and compares the actions of SGK3 and AKT in cell cycle regulation, oncogenic signalling, and the potential as a therapeutic target for cancer. KEY WORDS: SGK, AKT, PI3K, Cancer, Signalling, Kinase, Inhibitorhttp://www.sciencedirect.com/science/article/pii/S2211383518302442
collection DOAJ
language English
format Article
sources DOAJ
author Rajesh Basnet
Grace Qun Gong
Chenyao Li
Ming-Wei Wang
spellingShingle Rajesh Basnet
Grace Qun Gong
Chenyao Li
Ming-Wei Wang
Serum and glucocorticoid inducible protein kinases (SGKs): a potential target for cancer intervention
Acta Pharmaceutica Sinica B
author_facet Rajesh Basnet
Grace Qun Gong
Chenyao Li
Ming-Wei Wang
author_sort Rajesh Basnet
title Serum and glucocorticoid inducible protein kinases (SGKs): a potential target for cancer intervention
title_short Serum and glucocorticoid inducible protein kinases (SGKs): a potential target for cancer intervention
title_full Serum and glucocorticoid inducible protein kinases (SGKs): a potential target for cancer intervention
title_fullStr Serum and glucocorticoid inducible protein kinases (SGKs): a potential target for cancer intervention
title_full_unstemmed Serum and glucocorticoid inducible protein kinases (SGKs): a potential target for cancer intervention
title_sort serum and glucocorticoid inducible protein kinases (sgks): a potential target for cancer intervention
publisher Elsevier
series Acta Pharmaceutica Sinica B
issn 2211-3835
publishDate 2018-09-01
description The serum and glucocorticoid inducible protein kinase (SGK) family members share similar structure, substrate specificity and function with AKT and signal downstream of the phosphatidylinositol 3-kinase (PI3K) signalling pathway. They regulate a range of fundamental cellular processes such as cell proliferation and survival, thereby playing an important role in cancer development. This perspective intends to give an overview on the involvement of SGKs (particularly SGK3) in cancer progression, and compares the actions of SGK3 and AKT in cell cycle regulation, oncogenic signalling, and the potential as a therapeutic target for cancer. KEY WORDS: SGK, AKT, PI3K, Cancer, Signalling, Kinase, Inhibitor
url http://www.sciencedirect.com/science/article/pii/S2211383518302442
work_keys_str_mv AT rajeshbasnet serumandglucocorticoidinducibleproteinkinasessgksapotentialtargetforcancerintervention
AT gracequngong serumandglucocorticoidinducibleproteinkinasessgksapotentialtargetforcancerintervention
AT chenyaoli serumandglucocorticoidinducibleproteinkinasessgksapotentialtargetforcancerintervention
AT mingweiwang serumandglucocorticoidinducibleproteinkinasessgksapotentialtargetforcancerintervention
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