Evaluation of levels of oxidative stress as a potential biomarker in patients with rheumatoid arthritis
Objectives: One of the most prevalent autoimmune disease globally, rheumatoid arthritis (RA) is caused by interplay of multiple inflammatory mediators in specific joints. Altered redox balance is one of the key factors in pathophysiology of RA. This study aims to find whether oxidative stress in per...
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Online Access: | http://www.jfmpc.com/article.asp?issn=2249-4863;year=2021;volume=10;issue=5;spage=1981;epage=1986;aulast=Mukhopadhyay |
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doaj-14e9af00399b4b678a6b4741803526c82021-06-15T04:42:05ZengWolters Kluwer Medknow PublicationsJournal of Family Medicine and Primary Care2249-48632021-01-011051981198610.4103/jfmpc.jfmpc_2412_20Evaluation of levels of oxidative stress as a potential biomarker in patients with rheumatoid arthritisKaushik MukhopadhyaySoumita DeSunanda KunduParasar GhoshSuparna ChatterjeeMitali ChatterjeeObjectives: One of the most prevalent autoimmune disease globally, rheumatoid arthritis (RA) is caused by interplay of multiple inflammatory mediators in specific joints. Altered redox balance is one of the key factors in pathophysiology of RA. This study aims to find whether oxidative stress in peripheral blood neutrophil correlates with the disease activity and disability associated with it. Methods: Ten healthy controls and 29 RA patients with moderate to severe disease activity (DAS28 score >3.2) were recruited and reactive oxygen species (ROS) level in peripheral blood neutrophil was measured using flow cytometry at baseline visit and after 6 months follow-up. Functional status of RA patients was measured using Health Assessment Questionnaire Disability Index (HAQ-DI). Results: RA patients showed significantly higher level of ROS in compared to healthy control. DAS28 correlated well with ROS at baseline visit (Pearson's r = +0.63) as well as follow-up visit (Pearson's r = +0.75). HAQ-DI showed weak positive correlation at baseline visit (Pearson's r = 0.1) but it was negative at follow-up visit (Pearson's r = -0.19). Conclusions: Oxidative stress mirrors the disease activity in RA and can be considered as a biomarker, but it is not related with functional ability of the patients.http://www.jfmpc.com/article.asp?issn=2249-4863;year=2021;volume=10;issue=5;spage=1981;epage=1986;aulast=Mukhopadhyaydas28haq-dioxidative stressreactive oxygen speciesrheumatoid arthritis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Kaushik Mukhopadhyay Soumita De Sunanda Kundu Parasar Ghosh Suparna Chatterjee Mitali Chatterjee |
spellingShingle |
Kaushik Mukhopadhyay Soumita De Sunanda Kundu Parasar Ghosh Suparna Chatterjee Mitali Chatterjee Evaluation of levels of oxidative stress as a potential biomarker in patients with rheumatoid arthritis Journal of Family Medicine and Primary Care das28 haq-di oxidative stress reactive oxygen species rheumatoid arthritis |
author_facet |
Kaushik Mukhopadhyay Soumita De Sunanda Kundu Parasar Ghosh Suparna Chatterjee Mitali Chatterjee |
author_sort |
Kaushik Mukhopadhyay |
title |
Evaluation of levels of oxidative stress as a potential biomarker in patients with rheumatoid arthritis |
title_short |
Evaluation of levels of oxidative stress as a potential biomarker in patients with rheumatoid arthritis |
title_full |
Evaluation of levels of oxidative stress as a potential biomarker in patients with rheumatoid arthritis |
title_fullStr |
Evaluation of levels of oxidative stress as a potential biomarker in patients with rheumatoid arthritis |
title_full_unstemmed |
Evaluation of levels of oxidative stress as a potential biomarker in patients with rheumatoid arthritis |
title_sort |
evaluation of levels of oxidative stress as a potential biomarker in patients with rheumatoid arthritis |
publisher |
Wolters Kluwer Medknow Publications |
series |
Journal of Family Medicine and Primary Care |
issn |
2249-4863 |
publishDate |
2021-01-01 |
description |
Objectives: One of the most prevalent autoimmune disease globally, rheumatoid arthritis (RA) is caused by interplay of multiple inflammatory mediators in specific joints. Altered redox balance is one of the key factors in pathophysiology of RA. This study aims to find whether oxidative stress in peripheral blood neutrophil correlates with the disease activity and disability associated with it. Methods: Ten healthy controls and 29 RA patients with moderate to severe disease activity (DAS28 score >3.2) were recruited and reactive oxygen species (ROS) level in peripheral blood neutrophil was measured using flow cytometry at baseline visit and after 6 months follow-up. Functional status of RA patients was measured using Health Assessment Questionnaire Disability Index (HAQ-DI). Results: RA patients showed significantly higher level of ROS in compared to healthy control. DAS28 correlated well with ROS at baseline visit (Pearson's r = +0.63) as well as follow-up visit (Pearson's r = +0.75). HAQ-DI showed weak positive correlation at baseline visit (Pearson's r = 0.1) but it was negative at follow-up visit (Pearson's r = -0.19). Conclusions: Oxidative stress mirrors the disease activity in RA and can be considered as a biomarker, but it is not related with functional ability of the patients. |
topic |
das28 haq-di oxidative stress reactive oxygen species rheumatoid arthritis |
url |
http://www.jfmpc.com/article.asp?issn=2249-4863;year=2021;volume=10;issue=5;spage=1981;epage=1986;aulast=Mukhopadhyay |
work_keys_str_mv |
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