Risk Profile of Ischemic Stroke Caused by Small-Artery Occlusion vs. Deep Intracerebral Hemorrhage
Background: Small-artery occlusion (SAO) subtype accounts for a quarter of the cases of ischemic stroke and is mainly caused by pathological changes in cerebral small vessels, which also involve in deep intracerebral hemorrhage (dICH). However, the factors that drive some cases to SAO and others to...
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Frontiers Media S.A.
2019-11-01
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Online Access: | https://www.frontiersin.org/article/10.3389/fneur.2019.01213/full |
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Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Zimo Chen Zimo Chen Zimo Chen Zimo Chen Jinglin Mo Jinglin Mo Jinglin Mo Jinglin Mo Jie Xu Jie Xu Jie Xu Jie Xu Haiqiang Qin Haiqiang Qin Haiqiang Qin Haiqiang Qin Huaguang Zheng Huaguang Zheng Huaguang Zheng Huaguang Zheng Yuesong Pan Yuesong Pan Yuesong Pan Yuesong Pan Xia Meng Xia Meng Xia Meng Xia Meng Jing Jing Jing Jing Jing Jing Jing Jing Xianglong Xiang Xianglong Xiang Xianglong Xiang Yongjun Wang Yongjun Wang Yongjun Wang Yongjun Wang |
spellingShingle |
Zimo Chen Zimo Chen Zimo Chen Zimo Chen Jinglin Mo Jinglin Mo Jinglin Mo Jinglin Mo Jie Xu Jie Xu Jie Xu Jie Xu Haiqiang Qin Haiqiang Qin Haiqiang Qin Haiqiang Qin Huaguang Zheng Huaguang Zheng Huaguang Zheng Huaguang Zheng Yuesong Pan Yuesong Pan Yuesong Pan Yuesong Pan Xia Meng Xia Meng Xia Meng Xia Meng Jing Jing Jing Jing Jing Jing Jing Jing Xianglong Xiang Xianglong Xiang Xianglong Xiang Yongjun Wang Yongjun Wang Yongjun Wang Yongjun Wang Risk Profile of Ischemic Stroke Caused by Small-Artery Occlusion vs. Deep Intracerebral Hemorrhage Frontiers in Neurology cerebrovascular disease lacunar stroke intracerebral hemorrhage risk factor inflammation |
author_facet |
Zimo Chen Zimo Chen Zimo Chen Zimo Chen Jinglin Mo Jinglin Mo Jinglin Mo Jinglin Mo Jie Xu Jie Xu Jie Xu Jie Xu Haiqiang Qin Haiqiang Qin Haiqiang Qin Haiqiang Qin Huaguang Zheng Huaguang Zheng Huaguang Zheng Huaguang Zheng Yuesong Pan Yuesong Pan Yuesong Pan Yuesong Pan Xia Meng Xia Meng Xia Meng Xia Meng Jing Jing Jing Jing Jing Jing Jing Jing Xianglong Xiang Xianglong Xiang Xianglong Xiang Yongjun Wang Yongjun Wang Yongjun Wang Yongjun Wang |
author_sort |
Zimo Chen |
title |
Risk Profile of Ischemic Stroke Caused by Small-Artery Occlusion vs. Deep Intracerebral Hemorrhage |
title_short |
Risk Profile of Ischemic Stroke Caused by Small-Artery Occlusion vs. Deep Intracerebral Hemorrhage |
title_full |
Risk Profile of Ischemic Stroke Caused by Small-Artery Occlusion vs. Deep Intracerebral Hemorrhage |
title_fullStr |
Risk Profile of Ischemic Stroke Caused by Small-Artery Occlusion vs. Deep Intracerebral Hemorrhage |
title_full_unstemmed |
Risk Profile of Ischemic Stroke Caused by Small-Artery Occlusion vs. Deep Intracerebral Hemorrhage |
title_sort |
risk profile of ischemic stroke caused by small-artery occlusion vs. deep intracerebral hemorrhage |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Neurology |
issn |
1664-2295 |
publishDate |
2019-11-01 |
description |
Background: Small-artery occlusion (SAO) subtype accounts for a quarter of the cases of ischemic stroke and is mainly caused by pathological changes in cerebral small vessels, which also involve in deep intracerebral hemorrhage (dICH). However, the factors that drive some cases to SAO and others to dICH remained incompletely defined.Material and Methods: This study is a cross-sectional study from the China National Stroke Registry that included consecutive patients with ischemic stroke or intracerebral hemorrhage between August 2007 and September 2008. We compared the risk profile between the two subgroups using multivariable logistic regression.Results: A total of 1,135 patients with SAO stroke and 1,125 dICH patients were included for analyses. Generally, patients with SAO stroke were more likely to be male (odds ratio = 0.74, confidence interval = 0.58–0.94) and have diabetes (0.30, 0.22–0.40), higher atherogenic lipid profiles, higher body mass index (0.96, 0.94–0.99), higher waist/height ratio (0.12, 0.03–0.48), higher platelet count (0.84, 0.77–0.91), and higher proportion of abnormal estimated glomerular filtration rate (<90, ml/min/1.73 m2) (0.77, 0.62–0.95). Conversely, patients with dICH were more likely to have higher blood pressure parameters, inflammation levels (white blood cell count: 1.61, 1.48–1.76; high sensitivity C-reactive protein: 2.07, 1.36–3.16), and high-density lipoprotein-c (1.57, 1.25–1.98).Conclusions: The risk profile between SAO stroke and dICH were different. Furthermore, despite of traditional indexes, waist/height ratio, platelet count, inflammation levels, lipid profile, and estimated glomerular filtration rate also play important roles in driving arteriolosclerosis into opposite ends. |
topic |
cerebrovascular disease lacunar stroke intracerebral hemorrhage risk factor inflammation |
url |
https://www.frontiersin.org/article/10.3389/fneur.2019.01213/full |
work_keys_str_mv |
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doaj-14f4f8c8688e4f0583ca53a7f78bfdb72020-11-24T21:38:57ZengFrontiers Media S.A.Frontiers in Neurology1664-22952019-11-011010.3389/fneur.2019.01213492251Risk Profile of Ischemic Stroke Caused by Small-Artery Occlusion vs. Deep Intracerebral HemorrhageZimo Chen0Zimo Chen1Zimo Chen2Zimo Chen3Jinglin Mo4Jinglin Mo5Jinglin Mo6Jinglin Mo7Jie Xu8Jie Xu9Jie Xu10Jie Xu11Haiqiang Qin12Haiqiang Qin13Haiqiang Qin14Haiqiang Qin15Huaguang Zheng16Huaguang Zheng17Huaguang Zheng18Huaguang Zheng19Yuesong Pan20Yuesong Pan21Yuesong Pan22Yuesong Pan23Xia Meng24Xia Meng25Xia Meng26Xia Meng27Jing Jing28Jing Jing29Jing Jing30Jing Jing31Xianglong Xiang32Xianglong Xiang33Xianglong Xiang34Yongjun Wang35Yongjun Wang36Yongjun Wang37Yongjun Wang38Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaChina National Clinical Research Center for Neurological Diseases, Beijing, ChinaCenter of Stroke, Beijing Institute for Brain Disorders, Beijing, ChinaBeijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, ChinaDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaChina National Clinical Research Center for Neurological Diseases, Beijing, ChinaCenter of Stroke, Beijing Institute for Brain Disorders, Beijing, ChinaBeijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, ChinaDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaChina National Clinical Research Center for Neurological Diseases, Beijing, ChinaCenter of Stroke, Beijing Institute for Brain Disorders, Beijing, ChinaBeijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, ChinaDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaChina National Clinical Research Center for Neurological Diseases, Beijing, ChinaCenter of Stroke, Beijing Institute for Brain Disorders, Beijing, ChinaBeijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, ChinaDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaChina National Clinical Research Center for Neurological Diseases, Beijing, ChinaCenter of Stroke, Beijing Institute for Brain Disorders, Beijing, ChinaBeijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, ChinaDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaChina National Clinical Research Center for Neurological Diseases, Beijing, ChinaCenter of Stroke, Beijing Institute for Brain Disorders, Beijing, ChinaBeijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, ChinaDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaChina National Clinical Research Center for Neurological Diseases, Beijing, ChinaCenter of Stroke, Beijing Institute for Brain Disorders, Beijing, ChinaBeijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, ChinaDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaChina National Clinical Research Center for Neurological Diseases, Beijing, ChinaCenter of Stroke, Beijing Institute for Brain Disorders, Beijing, ChinaBeijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, ChinaChina National Clinical Research Center for Neurological Diseases, Beijing, ChinaCenter of Stroke, Beijing Institute for Brain Disorders, Beijing, ChinaBeijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, ChinaDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaChina National Clinical Research Center for Neurological Diseases, Beijing, ChinaCenter of Stroke, Beijing Institute for Brain Disorders, Beijing, ChinaBeijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, ChinaBackground: Small-artery occlusion (SAO) subtype accounts for a quarter of the cases of ischemic stroke and is mainly caused by pathological changes in cerebral small vessels, which also involve in deep intracerebral hemorrhage (dICH). However, the factors that drive some cases to SAO and others to dICH remained incompletely defined.Material and Methods: This study is a cross-sectional study from the China National Stroke Registry that included consecutive patients with ischemic stroke or intracerebral hemorrhage between August 2007 and September 2008. We compared the risk profile between the two subgroups using multivariable logistic regression.Results: A total of 1,135 patients with SAO stroke and 1,125 dICH patients were included for analyses. Generally, patients with SAO stroke were more likely to be male (odds ratio = 0.74, confidence interval = 0.58–0.94) and have diabetes (0.30, 0.22–0.40), higher atherogenic lipid profiles, higher body mass index (0.96, 0.94–0.99), higher waist/height ratio (0.12, 0.03–0.48), higher platelet count (0.84, 0.77–0.91), and higher proportion of abnormal estimated glomerular filtration rate (<90, ml/min/1.73 m2) (0.77, 0.62–0.95). Conversely, patients with dICH were more likely to have higher blood pressure parameters, inflammation levels (white blood cell count: 1.61, 1.48–1.76; high sensitivity C-reactive protein: 2.07, 1.36–3.16), and high-density lipoprotein-c (1.57, 1.25–1.98).Conclusions: The risk profile between SAO stroke and dICH were different. Furthermore, despite of traditional indexes, waist/height ratio, platelet count, inflammation levels, lipid profile, and estimated glomerular filtration rate also play important roles in driving arteriolosclerosis into opposite ends.https://www.frontiersin.org/article/10.3389/fneur.2019.01213/fullcerebrovascular diseaselacunar strokeintracerebral hemorrhagerisk factorinflammation |