Study progress of CCR3 in wet age-related macular degeneration

• Main Authors: Xian-Wei Wu, Zhe-Li Liu
• Format: Article
• Language: English
• Published: Press of International Journal of Ophthalmology (IJO PRESS) 2014-03-01
• Series: Guoji Yanke Zazhi
• Subjects: wet age-related macular degeneration; receptor; chemokine receptor 3
• Online Access: http://www.ies.net.cn/cn_publish/2014/3/201403020.pdf

According to the study, chemokine receptor 3(CCR3)in the eye is mainly distributed in retinal pigment epithelial cells, and also expressed in the choroidal vascular endothelial cells(CECs). The specificity of CCR3's high expression in wet age-related macular degeneration(AMD)was found, and it is proved that in wet-AMD patients, it plays an important role in the formation of choroidal neovascularization(CNV). In this paper, the structure, function, the problem of current research and the future direction of CCR3 were summarized. It is believed that with the further research on CCR3, it will not only help us to find a new method of wet-AMD diagnosis and treatment, but also may provide an important reference for other CNV disease research and new anti-CNV drugs.