Human Leptospirosis Trends: Northeast Thailand, 2001–2012

The objective of this study was to determine the changing trend of leptospirosis over time in Thailand using two prospective hospital-based studies conducted amongst adult patients with acute undifferentiated fever (AUFI) admitted to Maharat Nakhon Ratchasima Hospital, Nakhon Ratchasima Province, Th...

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Main Authors: Wilawan Thipmontree, Yupin Suputtamongkol, Wiwit Tantibhedhyangkul, Chuanpit Suttinont, Ekkarat Wongswat, Saowaluk Silpasakorn
Format: Article
Language:English
Published: MDPI AG 2014-08-01
Series:International Journal of Environmental Research and Public Health
Subjects:
Online Access:http://www.mdpi.com/1660-4601/11/8/8542
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spelling doaj-1500eb8fede844859dd713aa6cd2e5612020-11-24T23:18:54ZengMDPI AGInternational Journal of Environmental Research and Public Health1660-46012014-08-011188542855110.3390/ijerph110808542ijerph110808542Human Leptospirosis Trends: Northeast Thailand, 2001–2012Wilawan Thipmontree0Yupin Suputtamongkol1Wiwit Tantibhedhyangkul2Chuanpit Suttinont3Ekkarat Wongswat4Saowaluk Silpasakorn5Maharat Nakhon Ratchasima Hospital, Nakhon Ratchasima Province 30000, ThailandDepartment of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, ThailandDepartment of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, ThailandMaharat Nakhon Ratchasima Hospital, Nakhon Ratchasima Province 30000, ThailandDepartment of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, ThailandDepartment of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, ThailandThe objective of this study was to determine the changing trend of leptospirosis over time in Thailand using two prospective hospital-based studies conducted amongst adult patients with acute undifferentiated fever (AUFI) admitted to Maharat Nakhon Ratchasima Hospital, Nakhon Ratchasima Province, Thailand between July 2001 to December 2002 and between July 2011 to December 2012. During the first period, leptospirosis (98 patients, 40%) and scrub typhus (59 patients, 24.1%) were the two major causes of AUFI. In the second period, scrub typhus (137 patients, 28.3%) was found to be more common than leptospirosis (61 patients, 12.7%). Amongst patients with leptospirosis, the proportion of male patients and the median age were similar. Leptospira interrogans serogroup Autumnalis was the major infecting serogroup in both study periods. The case fatality rate of leptospirosis was significantly higher in 2011–2012 as compared with the case fatality rate in 2001–2002 (19.7% vs. 6.3%, p < 0.001). In summary, we found that number of leptospirosis cases had decreased over time. This trend is similar to reportable data for leptospirosis complied from passive surveillance by the Ministry of Public Health, Thailand. However, the case fatality rate of severe leptospirosis has increased. Severe lung hemorrhage associated with leptospirosis remained the major cause of death.http://www.mdpi.com/1660-4601/11/8/8542acute undifferentiated feverleptospirosislung hemorrhageThailand
collection DOAJ
language English
format Article
sources DOAJ
author Wilawan Thipmontree
Yupin Suputtamongkol
Wiwit Tantibhedhyangkul
Chuanpit Suttinont
Ekkarat Wongswat
Saowaluk Silpasakorn
spellingShingle Wilawan Thipmontree
Yupin Suputtamongkol
Wiwit Tantibhedhyangkul
Chuanpit Suttinont
Ekkarat Wongswat
Saowaluk Silpasakorn
Human Leptospirosis Trends: Northeast Thailand, 2001–2012
International Journal of Environmental Research and Public Health
acute undifferentiated fever
leptospirosis
lung hemorrhage
Thailand
author_facet Wilawan Thipmontree
Yupin Suputtamongkol
Wiwit Tantibhedhyangkul
Chuanpit Suttinont
Ekkarat Wongswat
Saowaluk Silpasakorn
author_sort Wilawan Thipmontree
title Human Leptospirosis Trends: Northeast Thailand, 2001–2012
title_short Human Leptospirosis Trends: Northeast Thailand, 2001–2012
title_full Human Leptospirosis Trends: Northeast Thailand, 2001–2012
title_fullStr Human Leptospirosis Trends: Northeast Thailand, 2001–2012
title_full_unstemmed Human Leptospirosis Trends: Northeast Thailand, 2001–2012
title_sort human leptospirosis trends: northeast thailand, 2001–2012
publisher MDPI AG
series International Journal of Environmental Research and Public Health
issn 1660-4601
publishDate 2014-08-01
description The objective of this study was to determine the changing trend of leptospirosis over time in Thailand using two prospective hospital-based studies conducted amongst adult patients with acute undifferentiated fever (AUFI) admitted to Maharat Nakhon Ratchasima Hospital, Nakhon Ratchasima Province, Thailand between July 2001 to December 2002 and between July 2011 to December 2012. During the first period, leptospirosis (98 patients, 40%) and scrub typhus (59 patients, 24.1%) were the two major causes of AUFI. In the second period, scrub typhus (137 patients, 28.3%) was found to be more common than leptospirosis (61 patients, 12.7%). Amongst patients with leptospirosis, the proportion of male patients and the median age were similar. Leptospira interrogans serogroup Autumnalis was the major infecting serogroup in both study periods. The case fatality rate of leptospirosis was significantly higher in 2011–2012 as compared with the case fatality rate in 2001–2002 (19.7% vs. 6.3%, p < 0.001). In summary, we found that number of leptospirosis cases had decreased over time. This trend is similar to reportable data for leptospirosis complied from passive surveillance by the Ministry of Public Health, Thailand. However, the case fatality rate of severe leptospirosis has increased. Severe lung hemorrhage associated with leptospirosis remained the major cause of death.
topic acute undifferentiated fever
leptospirosis
lung hemorrhage
Thailand
url http://www.mdpi.com/1660-4601/11/8/8542
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