Acute Liver Failure: Pathophysiologic Basis, and The Current and Emerging Therapies
Acute liver failure (ALF) is a devastating condition that occurs in patients who previously had a normal liver. Although the outcome of patients with ALF has improved, without liver transplantation (LT) mortality rates remain in the range of 35-50% in different geographical areas and therefore, its...
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2014-05-01
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doaj-1503840a285c499a9f50d5842fee9e522020-11-24T22:34:21ZengEuropean Medical JournalEuropean Medical Journal Hepatology2053-42212014-05-012199107Acute Liver Failure: Pathophysiologic Basis, and The Current and Emerging TherapiesGraziella Privitera0Banwari Agarwal1Rajiv Jalan2Department of Medicine, UCL Institute for Liver and Digestive Heath, University College London, Royal Free Hospital, London, United KingdomDepartment of Medicine, UCL Institute for Liver and Digestive Heath, University College London, Royal Free Hospital, London, United KingdomDepartment of Medicine, UCL Institute for Liver and Digestive Heath, University College London, Royal Free Hospital, London, United KingdomAcute liver failure (ALF) is a devastating condition that occurs in patients who previously had a normal liver. Although the outcome of patients with ALF has improved, without liver transplantation (LT) mortality rates remain in the range of 35-50% in different geographical areas and therefore, its treatment remains an unmet need. In the Western world toxic liver injury from acetaminophen remains one of the common causes but, in the East, hepatitis of unknown aetiology remains the most common cause. Treatment options are limited to meticulous attention to multi-organ support, use of N-acetyl cysteine, judicious use of antibiotics, and timely LT. This review describes the state-of-the-art techniques in the issues related to prognosis, outcome, and treatment of this devastating syndrome.http://emjreviews.com/wp-content/uploads/Acute-Liver-Failure-Pathophysiologic-Basis-And-The-Current-And-Emerging-Therapies.pdfacetaminophenintracranial hypertensionliver transplantationmulti-organ failureN-acetylcysteine |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Graziella Privitera Banwari Agarwal Rajiv Jalan |
spellingShingle |
Graziella Privitera Banwari Agarwal Rajiv Jalan Acute Liver Failure: Pathophysiologic Basis, and The Current and Emerging Therapies European Medical Journal Hepatology acetaminophen intracranial hypertension liver transplantation multi-organ failure N-acetylcysteine |
author_facet |
Graziella Privitera Banwari Agarwal Rajiv Jalan |
author_sort |
Graziella Privitera |
title |
Acute Liver Failure: Pathophysiologic Basis, and The Current and Emerging Therapies |
title_short |
Acute Liver Failure: Pathophysiologic Basis, and The Current and Emerging Therapies |
title_full |
Acute Liver Failure: Pathophysiologic Basis, and The Current and Emerging Therapies |
title_fullStr |
Acute Liver Failure: Pathophysiologic Basis, and The Current and Emerging Therapies |
title_full_unstemmed |
Acute Liver Failure: Pathophysiologic Basis, and The Current and Emerging Therapies |
title_sort |
acute liver failure: pathophysiologic basis, and the current and emerging therapies |
publisher |
European Medical Journal |
series |
European Medical Journal Hepatology |
issn |
2053-4221 |
publishDate |
2014-05-01 |
description |
Acute liver failure (ALF) is a devastating condition that occurs in patients who previously had a normal liver. Although the outcome of patients with ALF has improved, without liver transplantation (LT) mortality rates remain in the range of 35-50% in different geographical areas and therefore, its treatment remains an unmet need. In the Western world toxic liver injury from acetaminophen remains one of the common causes but, in the East, hepatitis of unknown aetiology remains the most common cause. Treatment options are limited to meticulous attention to multi-organ support, use of N-acetyl cysteine, judicious use of antibiotics, and timely LT. This review describes the state-of-the-art techniques in the issues related to prognosis, outcome, and treatment of this devastating syndrome. |
topic |
acetaminophen intracranial hypertension liver transplantation multi-organ failure N-acetylcysteine |
url |
http://emjreviews.com/wp-content/uploads/Acute-Liver-Failure-Pathophysiologic-Basis-And-The-Current-And-Emerging-Therapies.pdf |
work_keys_str_mv |
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