Advances of stem cell based-therapeutic approaches for tendon repair

• Main Authors: Lidi Liu, Jennifer Hindieh, Daniel J. Leong, Hui B. Sun
• Format: Article
• Language: English
• Published: Elsevier 2017-04-01
• Series: Journal of Orthopaedic Translation
• Subjects: stem cells; tendinopathy; tendon repair
• Online Access: http://www.sciencedirect.com/science/article/pii/S2214031X16302844

Tendon injuries are significant clinical problems. Current treatments often result in incomplete repair or healing, which may lead to reduced function and rupture. Stem cell-based therapy is a promising intervention for tendon repair. In this article, we attempt to provide a brief overview on the recent progress in the field, current understanding of the underlying mechanisms of the approach, and the potential of stem cell-based therapies beyond cell implantation. We conclude the review by sharing our viewpoints on the challenges, opportunities, and future directions of this approach. The translational potential of this article: This paper reviews recent progress on stem cell-based therapeutic approaches for tendon repair, which highlights its translational potential and challenges.