Characterization and in vitro release studies of oral microbeads containing thiolated pectin–doxorubicin conjugates for colorectal cancer treatment
Novel oral microbeads were developed based on a biopolymer–drug conjugate of doxorubicin (DOX) conjugated with thiolated pectin via reducible disulfide bonds. The microbeads were fabricated by ionotropic gelation with cations such as Al3+, Ca2+ and Zn2+. The results showed that using zinc acetate ca...
Main Authors: | Kamonrak Cheewatanakornkool, Sathit Niratisai, Somkamol Manchun, Crispin R. Dass, Pornsak Sriamornsak |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2017-11-01
|
Series: | Asian Journal of Pharmaceutical Sciences |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S1818087617304750 |
Similar Items
-
Bioadhesiveness of thiolated pectin for buccal delivery of carbenoxolone sodium
by: Kamonrak Cheewatanakornkool, et al.
Published: (2016-02-01) -
Electrosprayed Core–Shell Composite Microbeads Based on Pectin-Arabinoxylans for Insulin Carrying: Aggregation and Size Dispersion Control
by: Agustín Rascón-Chu, et al.
Published: (2018-01-01) -
Hybrid Acrylated Chitosan and Thiolated Pectin Cross-Linked Hydrogels with Tunable Properties
by: Shaked Eliyahu, et al.
Published: (2021-01-01) -
The effect of modified citrus pectin-probiotic on faecal lactobacilli in Balb/c mice
by: Frederick ODUN-AYO, et al. -
Doxorubicin: The dogma and the bone
by: Jia Y. Wong, et al.
Published: (2016-02-01)