Manifestation of Systemic Toxicity in Rats after a Short-Time Inhalation of Lead Oxide Nanoparticles

• Main Authors: Marina P. Sutunkova, Svetlana N. Solovyeva, Ivan N. Chernyshov, Svetlana V. Klinova, Vladimir B. Gurvich, Vladimir Ya. Shur, Ekaterina V. Shishkina, Ilya V. Zubarev, Larisa I. Privalova, Boris A. Katsnelson
• Format: Article
• Language: English
• Published: MDPI AG 2020-01-01
• Series: International Journal of Molecular Sciences
• Subjects: nanoparticles; lead oxide; inhalation exposure; toxicity
• Online Access: https://www.mdpi.com/1422-0067/21/3/690

Outbred female rats were exposed to inhalation of lead oxide nanoparticle aerosol produced right then and there at a concentration of 1.30 ± 0.10 mg/m³ during 5 days for 4 h a day in a nose-only setup. A control group of rats were sham-exposed in parallel under similar conditions. Even this short-time exposure of a relatively low level was associated with nanoparticles retention demonstrable by transmission electron microscopy in the lungs and the olfactory brain. Some impairments were found in the organism’s status in the exposed group, some of which might be considered lead-specific toxicological outcomes (in particular, increase in reticulocytes proportion, in δ-aminolevulinic acid (δ-ALA) urine excretion, and the arterial hypertension’s development).