Sensitive detection of Aβ protofibrils by proximity ligation - relevance for Alzheimer's disease

<p>Abstract</p> <p>Background</p> <p>Protein aggregation plays important roles in several neurodegenerative disorders. For instance, insoluble aggregates of phosphorylated tau and of Aβ peptides are cornerstones in the pathology of Alzheimer's disease. Soluble prot...

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Main Authors: Gustafsdottir Sigrun, Sehlin Dag, Tavoosidana Gholamreza, Lord Anna, Darmanis Spyros, Englund Hillevi, Wu Di, Pettersson Frida, Kamali-Moghaddam Masood, Nilsson Lars NG, Lannfelt Lars, Landegren Ulf
Format: Article
Language:English
Published: BMC 2010-10-01
Series:BMC Neuroscience
Online Access:http://www.biomedcentral.com/1471-2202/11/124