Incidence and Risk Factors of Necrotizing Enterocolitis Following Gastroschisis Repair in Correlation with Modes of Abdominal Wall Closure and Umbilical Management at Siriraj Hospital: an 11-Year Retrospective Review
Objective: We investigated the correlation between umbilical management and NEC in infants with gastroschisis as well as the incidence and potential risk factors of NEC in patients with gastroschisis at Siriraj Hospital from 2005 to 2016. Methods: A retrospective chart review was conducted of patie...
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doaj-1542cd3597164b999db4fee75c7d45c82021-08-13T09:47:41ZengMahidol UniversitySiriraj Medical Journal2228-80822019-07-01714Incidence and Risk Factors of Necrotizing Enterocolitis Following Gastroschisis Repair in Correlation with Modes of Abdominal Wall Closure and Umbilical Management at Siriraj Hospital: an 11-Year Retrospective ReviewMongkol Laohapensang0Duangkamol Puthakunraksa1Niramol Tantemsapya2Department of Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700Department of Surgery, Chareonkrung Pracharak Hospital, Bangkok 10120Department of Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700 Objective: We investigated the correlation between umbilical management and NEC in infants with gastroschisis as well as the incidence and potential risk factors of NEC in patients with gastroschisis at Siriraj Hospital from 2005 to 2016. Methods: A retrospective chart review was conducted of patients with gastroschisis who were surgically repaired at Siriraj Hospital from January 2005 to January 2016. The baseline characteristics, umbilical management, and short-term outcomes were analyzed in relation to NEC complications to determine the associated correlations and potential risk factors. Results: Overall, 106 patients were enrolled. The incidence of NEC following gastroschisis repair was 16% (17/106). Umbilical preservation was a significant potential risk factor for NEC (p = 0.009; hazard ratio = 5.14; 95% CI = 1.51-17.42). There were no significant differences between the NEC and non-NEC group for gender, median Apgar scores, gestational ages, and birth weight. The short-term outcomes were significantly higher for the NEC than the non-NEC group, with a time to first oral feeding of 15 vs. 9 days (p = 0.006), duration of total parenteral nutrition, 22 vs. 12 days (p < 0.001), and length of stay, 32 vs. 23 days (p = 0.01) respectively. Conclusion: Umbilical preservation following gastroschisis repair was associated with a higher incidence of NEC, even in term infants. Thus, NEC should be carefully monitored after abdominal fascial closure with umbilical preservation. https://he02.tci-thaijo.org/index.php/sirirajmedj/article/view/205199NEC; gastroschisis; umbilical preservation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mongkol Laohapensang Duangkamol Puthakunraksa Niramol Tantemsapya |
spellingShingle |
Mongkol Laohapensang Duangkamol Puthakunraksa Niramol Tantemsapya Incidence and Risk Factors of Necrotizing Enterocolitis Following Gastroschisis Repair in Correlation with Modes of Abdominal Wall Closure and Umbilical Management at Siriraj Hospital: an 11-Year Retrospective Review Siriraj Medical Journal NEC; gastroschisis; umbilical preservation |
author_facet |
Mongkol Laohapensang Duangkamol Puthakunraksa Niramol Tantemsapya |
author_sort |
Mongkol Laohapensang |
title |
Incidence and Risk Factors of Necrotizing Enterocolitis Following Gastroschisis Repair in Correlation with Modes of Abdominal Wall Closure and Umbilical Management at Siriraj Hospital: an 11-Year Retrospective Review |
title_short |
Incidence and Risk Factors of Necrotizing Enterocolitis Following Gastroschisis Repair in Correlation with Modes of Abdominal Wall Closure and Umbilical Management at Siriraj Hospital: an 11-Year Retrospective Review |
title_full |
Incidence and Risk Factors of Necrotizing Enterocolitis Following Gastroschisis Repair in Correlation with Modes of Abdominal Wall Closure and Umbilical Management at Siriraj Hospital: an 11-Year Retrospective Review |
title_fullStr |
Incidence and Risk Factors of Necrotizing Enterocolitis Following Gastroschisis Repair in Correlation with Modes of Abdominal Wall Closure and Umbilical Management at Siriraj Hospital: an 11-Year Retrospective Review |
title_full_unstemmed |
Incidence and Risk Factors of Necrotizing Enterocolitis Following Gastroschisis Repair in Correlation with Modes of Abdominal Wall Closure and Umbilical Management at Siriraj Hospital: an 11-Year Retrospective Review |
title_sort |
incidence and risk factors of necrotizing enterocolitis following gastroschisis repair in correlation with modes of abdominal wall closure and umbilical management at siriraj hospital: an 11-year retrospective review |
publisher |
Mahidol University |
series |
Siriraj Medical Journal |
issn |
2228-8082 |
publishDate |
2019-07-01 |
description |
Objective: We investigated the correlation between umbilical management and NEC in infants with gastroschisis as well as the incidence and potential risk factors of NEC in patients with gastroschisis at Siriraj Hospital from 2005 to 2016.
Methods: A retrospective chart review was conducted of patients with gastroschisis who were surgically repaired at Siriraj Hospital from January 2005 to January 2016. The baseline characteristics, umbilical management, and short-term outcomes were analyzed in relation to NEC complications to determine the associated correlations and potential risk factors.
Results: Overall, 106 patients were enrolled. The incidence of NEC following gastroschisis repair was 16% (17/106). Umbilical preservation was a significant potential risk factor for NEC (p = 0.009; hazard ratio = 5.14; 95% CI = 1.51-17.42). There were no significant differences between the NEC and non-NEC group for gender, median Apgar
scores, gestational ages, and birth weight. The short-term outcomes were significantly higher for the NEC than the non-NEC group, with a time to first oral feeding of 15 vs. 9 days (p = 0.006), duration of total parenteral nutrition, 22 vs. 12 days (p < 0.001), and length of stay, 32 vs. 23 days (p = 0.01) respectively.
Conclusion: Umbilical preservation following gastroschisis repair was associated with a higher incidence of NEC, even in term infants. Thus, NEC should be carefully monitored after abdominal fascial closure with umbilical preservation.
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topic |
NEC; gastroschisis; umbilical preservation |
url |
https://he02.tci-thaijo.org/index.php/sirirajmedj/article/view/205199 |
work_keys_str_mv |
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