The Current State and Future of CRISPR-Cas9 gRNA Design Tools

The Current State and Future of CRISPR-Cas9 gRNA Design Tools

Recent years have seen the development of computational tools to assist researchers in performing CRISPR-Cas9 experiment optimally. More specifically, these tools aim to maximize on-target activity (guide efficiency) while also minimizing potential off-target effects (guide specificity) by analyzing...

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Bibliographic Details
Main Authors: Laurence O. W. Wilson, Aidan R. O’Brien, Denis C. Bauer
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Pharmacology
Subjects:
CRISPR-Cas9
bioinformatics
off-target finder
activity prediction
chromatin
machine learning
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.00749/full

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