Beta-lactamase database (BLDB) – structure and function
Beta-Lactamase Database (BLDB) is a comprehensive, manually curated public resource providing up-to-date structural and functional information focused on this superfamily of enzymes with a great impact on antibiotic resistance. All the enzymes reported and characterised in the literature are present...
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Online Access: | http://dx.doi.org/10.1080/14756366.2017.1344235 |
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doaj-154e783ec8da460caaab16190765098d2020-11-25T02:01:55ZengTaylor & Francis GroupJournal of Enzyme Inhibition and Medicinal Chemistry1475-63661475-63742017-01-0132191791910.1080/14756366.2017.13442351344235Beta-lactamase database (BLDB) – structure and functionThierry Naas0Saoussen Oueslati1Rémy A. Bonnin2Maria Laura Dabos3Agustin Zavala4Laurent Dortet5Pascal Retailleau6Bogdan I. Iorga7Université et Faculté de Médecine Paris-Sud, LabEx LERMITUniversité et Faculté de Médecine Paris-Sud, LabEx LERMITUniversité et Faculté de Médecine Paris-Sud, LabEx LERMITUniversité et Faculté de Médecine Paris-Sud, LabEx LERMITUniversité et Faculté de Médecine Paris-Sud, LabEx LERMITUniversité et Faculté de Médecine Paris-Sud, LabEx LERMITUniversité Paris-Saclay, LabEx LERMITUniversité Paris-Saclay, LabEx LERMITBeta-Lactamase Database (BLDB) is a comprehensive, manually curated public resource providing up-to-date structural and functional information focused on this superfamily of enzymes with a great impact on antibiotic resistance. All the enzymes reported and characterised in the literature are presented according to the class (A, B, C and D), family and subfamily to which they belong. All three-dimensional structures of β-lactamases present in the Protein Data Bank are also shown. The characterisation of representative mutants and hydrolytic profiles (kinetics) completes the picture and altogether these four elements constitute the essential foundation for a better understanding of the structure-function relationship within this enzymes family. BLDB can be queried using different protein- and nucleotide-based BLAST searches, which represents a key feature of particular importance in the context of the surveillance of the evolution of the antibiotic resistance. BLDB is available online at http://bldb.eu without any registration and supports all modern browsers.http://dx.doi.org/10.1080/14756366.2017.1344235Databasebeta-lactamaseantibiotic resistancehydrolytic profilemutant |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Thierry Naas Saoussen Oueslati Rémy A. Bonnin Maria Laura Dabos Agustin Zavala Laurent Dortet Pascal Retailleau Bogdan I. Iorga |
spellingShingle |
Thierry Naas Saoussen Oueslati Rémy A. Bonnin Maria Laura Dabos Agustin Zavala Laurent Dortet Pascal Retailleau Bogdan I. Iorga Beta-lactamase database (BLDB) – structure and function Journal of Enzyme Inhibition and Medicinal Chemistry Database beta-lactamase antibiotic resistance hydrolytic profile mutant |
author_facet |
Thierry Naas Saoussen Oueslati Rémy A. Bonnin Maria Laura Dabos Agustin Zavala Laurent Dortet Pascal Retailleau Bogdan I. Iorga |
author_sort |
Thierry Naas |
title |
Beta-lactamase database (BLDB) – structure and function |
title_short |
Beta-lactamase database (BLDB) – structure and function |
title_full |
Beta-lactamase database (BLDB) – structure and function |
title_fullStr |
Beta-lactamase database (BLDB) – structure and function |
title_full_unstemmed |
Beta-lactamase database (BLDB) – structure and function |
title_sort |
beta-lactamase database (bldb) – structure and function |
publisher |
Taylor & Francis Group |
series |
Journal of Enzyme Inhibition and Medicinal Chemistry |
issn |
1475-6366 1475-6374 |
publishDate |
2017-01-01 |
description |
Beta-Lactamase Database (BLDB) is a comprehensive, manually curated public resource providing up-to-date structural and functional information focused on this superfamily of enzymes with a great impact on antibiotic resistance. All the enzymes reported and characterised in the literature are presented according to the class (A, B, C and D), family and subfamily to which they belong. All three-dimensional structures of β-lactamases present in the Protein Data Bank are also shown. The characterisation of representative mutants and hydrolytic profiles (kinetics) completes the picture and altogether these four elements constitute the essential foundation for a better understanding of the structure-function relationship within this enzymes family. BLDB can be queried using different protein- and nucleotide-based BLAST searches, which represents a key feature of particular importance in the context of the surveillance of the evolution of the antibiotic resistance. BLDB is available online at http://bldb.eu without any registration and supports all modern browsers. |
topic |
Database beta-lactamase antibiotic resistance hydrolytic profile mutant |
url |
http://dx.doi.org/10.1080/14756366.2017.1344235 |
work_keys_str_mv |
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