Protective effect of Nigella sativa on sperm parameters in mice exposed to titanium dioxide during embryonic development
Background and Aim: Nanotechnology is the precise and controlled manipulation of the atomic or molecular structure of nanoscale materials for the preparation of particulate matter with new properties and specific applications. Many in vivo and in vitro studies have shown the negative and destructive...
Main Authors: | , , , , , , , |
---|---|
Format: | Article |
Language: | fas |
Published: |
Kurdistan University of Medical Sciences
2019-06-01
|
Series: | مجله علمی دانشگاه علوم پزشکی کردستان |
Subjects: | |
Online Access: | http://sjku.muk.ac.ir/article-1-4474-en.html |
id |
doaj-155c50cf0b614c6598f878551616d915 |
---|---|
record_format |
Article |
spelling |
doaj-155c50cf0b614c6598f878551616d9152020-12-27T07:57:30Zfas Kurdistan University of Medical Sciencesمجله علمی دانشگاه علوم پزشکی کردستان1560-652X2345-40402019-06-012426673Protective effect of Nigella sativa on sperm parameters in mice exposed to titanium dioxide during embryonic developmentMorteza Abouzaripour0Mehdi Hosaini bae1Mohammad Jafar Rezaie2Bahram Nikkho3Azra Allahveisi4Daem Roshani5Shiva Khalesro6erfan daneshi7 Cellular and Molecular Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran. Cellular and Molecular Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran. Infertility Treatment Center, Besat Hospital, Kurdistan University of Medical Sciences, Sanandaj, Iran. Department of Pathology, School of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran. Infertility Treatment Center, Besat Hospital, Kurdistan University of Medical Sciences, Sanandaj, Iran. Social Determinants of Health Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran. Department of Agronomy and Plant Breeding, Faculty of Agriculture, University of Kurdistan, Sanandaj, Iran. Cellular and Molecular Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran Background and Aim: Nanotechnology is the precise and controlled manipulation of the atomic or molecular structure of nanoscale materials for the preparation of particulate matter with new properties and specific applications. Many in vivo and in vitro studies have shown the negative and destructive effects of nanoparticles on male germ cells.Nanoparticles include primary particles with at least one of their dimensions less than 100 nm. Material and Method: This study included 20 male and female adult mice (NMRI), between 6 and 8 weeks of age and weight of 25-30 g. We placed every two adult female mice with a male adult mouse in a cage for mating. Pregnant mice were randomly divided into 4 groups.)control,titanium, nigella sativa,titanium +nigella sativa). Animals were sacrificed by cervical spine dislocation under anesthesia. Then, using a neobar lamel and under the optical microscope, number of sperms and their morphology were assessed. Result: In this study, semen parameters including sperm morphology and number and also weights of organs were assessed. We found decreased number of sperms, increased number of abnormal sperms and decreased weight in the titanium group. But protective effect of Nigella sativa in the treatment group led to a significant difference in the sperm parameters compared to that in the titanium group (p>0.05). Conclusion: TNP reduced sperm count and increased the number of abnormal sperms, Previous studies by Hajshafiha showed the ability of nanoparticles to cross the blood-testicular barrier. Protective and antioxidant effects of Nigella sativa can greatly reduce the toxicity of TNP. NS had a potent protective effect against the toxic effect of TNP on testese.http://sjku.muk.ac.ir/article-1-4474-en.htmltitanium nanoparticlenigella sativaparameter |
collection |
DOAJ |
language |
fas |
format |
Article |
sources |
DOAJ |
author |
Morteza Abouzaripour Mehdi Hosaini bae Mohammad Jafar Rezaie Bahram Nikkho Azra Allahveisi Daem Roshani Shiva Khalesro erfan daneshi |
spellingShingle |
Morteza Abouzaripour Mehdi Hosaini bae Mohammad Jafar Rezaie Bahram Nikkho Azra Allahveisi Daem Roshani Shiva Khalesro erfan daneshi Protective effect of Nigella sativa on sperm parameters in mice exposed to titanium dioxide during embryonic development مجله علمی دانشگاه علوم پزشکی کردستان titanium nanoparticle nigella sativa parameter |
author_facet |
Morteza Abouzaripour Mehdi Hosaini bae Mohammad Jafar Rezaie Bahram Nikkho Azra Allahveisi Daem Roshani Shiva Khalesro erfan daneshi |
author_sort |
Morteza Abouzaripour |
title |
Protective effect of Nigella sativa on sperm parameters in mice exposed to titanium dioxide during embryonic development |
title_short |
Protective effect of Nigella sativa on sperm parameters in mice exposed to titanium dioxide during embryonic development |
title_full |
Protective effect of Nigella sativa on sperm parameters in mice exposed to titanium dioxide during embryonic development |
title_fullStr |
Protective effect of Nigella sativa on sperm parameters in mice exposed to titanium dioxide during embryonic development |
title_full_unstemmed |
Protective effect of Nigella sativa on sperm parameters in mice exposed to titanium dioxide during embryonic development |
title_sort |
protective effect of nigella sativa on sperm parameters in mice exposed to titanium dioxide during embryonic development |
publisher |
Kurdistan University of Medical Sciences |
series |
مجله علمی دانشگاه علوم پزشکی کردستان |
issn |
1560-652X 2345-4040 |
publishDate |
2019-06-01 |
description |
Background and Aim: Nanotechnology is the precise and controlled manipulation of the atomic or molecular structure of nanoscale materials for the preparation of particulate matter with new properties and specific applications. Many in vivo and in vitro studies have shown the negative and destructive effects of nanoparticles on male germ cells.Nanoparticles include primary particles with at least one of their dimensions less than 100 nm.
Material and Method: This study included 20 male and female adult mice (NMRI), between 6 and 8 weeks of age and weight of 25-30 g. We placed every two adult female mice with a male adult mouse in a cage for mating. Pregnant mice were randomly divided into 4 groups.)control,titanium, nigella sativa,titanium +nigella sativa). Animals were sacrificed by cervical spine dislocation under anesthesia. Then, using a neobar lamel and under the optical microscope, number of sperms and their morphology were assessed.
Result: In this study, semen parameters including sperm morphology and number and also weights of organs were assessed. We found decreased number of sperms, increased number of abnormal sperms and decreased weight in the titanium group. But protective effect of Nigella sativa in the treatment group led to a significant difference in the sperm parameters compared to that in the titanium group (p>0.05).
Conclusion: TNP reduced sperm count and increased the number of abnormal sperms, Previous studies by Hajshafiha showed the ability of nanoparticles to cross the blood-testicular barrier. Protective and antioxidant effects of Nigella sativa can greatly reduce the toxicity of TNP. NS had a potent protective effect against the toxic effect of TNP on testese. |
topic |
titanium nanoparticle nigella sativa parameter |
url |
http://sjku.muk.ac.ir/article-1-4474-en.html |
work_keys_str_mv |
AT mortezaabouzaripour protectiveeffectofnigellasativaonspermparametersinmiceexposedtotitaniumdioxideduringembryonicdevelopment AT mehdihosainibae protectiveeffectofnigellasativaonspermparametersinmiceexposedtotitaniumdioxideduringembryonicdevelopment AT mohammadjafarrezaie protectiveeffectofnigellasativaonspermparametersinmiceexposedtotitaniumdioxideduringembryonicdevelopment AT bahramnikkho protectiveeffectofnigellasativaonspermparametersinmiceexposedtotitaniumdioxideduringembryonicdevelopment AT azraallahveisi protectiveeffectofnigellasativaonspermparametersinmiceexposedtotitaniumdioxideduringembryonicdevelopment AT daemroshani protectiveeffectofnigellasativaonspermparametersinmiceexposedtotitaniumdioxideduringembryonicdevelopment AT shivakhalesro protectiveeffectofnigellasativaonspermparametersinmiceexposedtotitaniumdioxideduringembryonicdevelopment AT erfandaneshi protectiveeffectofnigellasativaonspermparametersinmiceexposedtotitaniumdioxideduringembryonicdevelopment |
_version_ |
1724369638600474624 |