Differential expression of A-type and B-type lamins during hair cycling.
Multiple genetic disorders caused by mutations that affect the proteins lamin A and C show strong skin phenotypes. These disorders include the premature aging disorders Hutchinson-Gilford progeria syndrome and mandibuloacral dysplasia, as well as restrictive dermopathy. Prior studies have shown that...
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2009-01-01
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doaj-156ebb5806ca41be8d8f07dde20dffe32020-11-25T01:44:30ZengPublic Library of Science (PLoS)PLoS ONE1932-62032009-01-0141e411410.1371/journal.pone.0004114Differential expression of A-type and B-type lamins during hair cycling.Mubashir HanifYlva RosengardtenHanna SageliusBjörn RozellMaria ErikssonMultiple genetic disorders caused by mutations that affect the proteins lamin A and C show strong skin phenotypes. These disorders include the premature aging disorders Hutchinson-Gilford progeria syndrome and mandibuloacral dysplasia, as well as restrictive dermopathy. Prior studies have shown that the lamin A/C and B proteins are expressed in skin, but little is known about their normal expression in the different skin cell-types and during the hair cycle. Our immunohistochemical staining for lamins A/C and B in wild-type mice revealed strong expression in the basal cell layer of the epidermis, the outer root sheath, and the dermal papilla during all stages of the hair cycle. Lower expression of both lamins A/C and B was seen in suprabasal cells of the epidermis, in the hypodermis, and in the bulb of catagen follicles. In addition, we have utilized a previously described mouse model of Hutchinson-Gilford progeria syndrome and show here that the expression of progerin does not result in pronounced effects on hair cycling or the expression of lamin B.http://europepmc.org/articles/PMC2606029?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mubashir Hanif Ylva Rosengardten Hanna Sagelius Björn Rozell Maria Eriksson |
spellingShingle |
Mubashir Hanif Ylva Rosengardten Hanna Sagelius Björn Rozell Maria Eriksson Differential expression of A-type and B-type lamins during hair cycling. PLoS ONE |
author_facet |
Mubashir Hanif Ylva Rosengardten Hanna Sagelius Björn Rozell Maria Eriksson |
author_sort |
Mubashir Hanif |
title |
Differential expression of A-type and B-type lamins during hair cycling. |
title_short |
Differential expression of A-type and B-type lamins during hair cycling. |
title_full |
Differential expression of A-type and B-type lamins during hair cycling. |
title_fullStr |
Differential expression of A-type and B-type lamins during hair cycling. |
title_full_unstemmed |
Differential expression of A-type and B-type lamins during hair cycling. |
title_sort |
differential expression of a-type and b-type lamins during hair cycling. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2009-01-01 |
description |
Multiple genetic disorders caused by mutations that affect the proteins lamin A and C show strong skin phenotypes. These disorders include the premature aging disorders Hutchinson-Gilford progeria syndrome and mandibuloacral dysplasia, as well as restrictive dermopathy. Prior studies have shown that the lamin A/C and B proteins are expressed in skin, but little is known about their normal expression in the different skin cell-types and during the hair cycle. Our immunohistochemical staining for lamins A/C and B in wild-type mice revealed strong expression in the basal cell layer of the epidermis, the outer root sheath, and the dermal papilla during all stages of the hair cycle. Lower expression of both lamins A/C and B was seen in suprabasal cells of the epidermis, in the hypodermis, and in the bulb of catagen follicles. In addition, we have utilized a previously described mouse model of Hutchinson-Gilford progeria syndrome and show here that the expression of progerin does not result in pronounced effects on hair cycling or the expression of lamin B. |
url |
http://europepmc.org/articles/PMC2606029?pdf=render |
work_keys_str_mv |
AT mubashirhanif differentialexpressionofatypeandbtypelaminsduringhaircycling AT ylvarosengardten differentialexpressionofatypeandbtypelaminsduringhaircycling AT hannasagelius differentialexpressionofatypeandbtypelaminsduringhaircycling AT bjornrozell differentialexpressionofatypeandbtypelaminsduringhaircycling AT mariaeriksson differentialexpressionofatypeandbtypelaminsduringhaircycling |
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