Cyclin-Dependent Kinase 5 (CDK5)-Mediated Phosphorylation of Upstream Stimulatory Factor 2 (USF2) Contributes to Carcinogenesis

Cyclin-Dependent Kinase 5 (CDK5)-Mediated Phosphorylation of Upstream Stimulatory Factor 2 (USF2) Contributes to Carcinogenesis

The transcription factor USF2 is supposed to have an important role in tumor development. However, the regulatory mechanisms contributing to the function of USF2 are largely unknown. Cyclin-dependent kinase 5 (CDK5) seems to be of importance since high levels of CDK5 were found in different cancers...

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Bibliographic Details
Main Authors: Tabughang Franklin Chi, Tina Horbach, Claudia Götz, Thomas Kietzmann, Elitsa Y. Dimova
Format: Article
Language:English
Published: MDPI AG 2019-04-01
Series:Cancers
Subjects:
upstream stimulatory factor 2 (USF2)
cyclin-dependent kinase-5 (CDK5)
CRISPR-Cas9
phosphorylation
proliferation
migration
Online Access:https://www.mdpi.com/2072-6694/11/4/523

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