Zika Infection Disrupts Proteins Involved in the Neurosensory System
Newly re-emerging viruses are of great global concern, especially when there are no therapeutic interventions available during the time of an outbreak. There are still no therapeutic interventions for the prevention of Zika virus (ZIKV) infections despite its resurgence more than a decade ago. Newbo...
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doaj-157bfc52d7d9459995fc63846c71f7b42020-11-25T02:56:32ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2020-07-01810.3389/fcell.2020.00571540168Zika Infection Disrupts Proteins Involved in the Neurosensory SystemKathleen K. M. Glover0Kathleen K. M. Glover1Ali Zahedi-Amiri2Ali Zahedi-Amiri3Ying Lao4Victor Spicer5Thomas Klonisch6Thomas Klonisch7Thomas Klonisch8Kevin M. Coombs9Kevin M. Coombs10Kevin M. Coombs11Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, MB, CanadaManitoba Centre for Proteomics and Systems Biology, Winnipeg, MB, CanadaDepartment of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, MB, CanadaManitoba Centre for Proteomics and Systems Biology, Winnipeg, MB, CanadaManitoba Centre for Proteomics and Systems Biology, Winnipeg, MB, CanadaManitoba Centre for Proteomics and Systems Biology, Winnipeg, MB, CanadaDepartment of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, MB, CanadaDepartment of Human Anatomy and Cell Science, University of Manitoba, Winnipeg, MB, CanadaJohn Buhler Research Centre, Children’s Hospital Research Institute of Manitoba, Winnipeg, MB, CanadaDepartment of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, MB, CanadaManitoba Centre for Proteomics and Systems Biology, Winnipeg, MB, CanadaJohn Buhler Research Centre, Children’s Hospital Research Institute of Manitoba, Winnipeg, MB, CanadaNewly re-emerging viruses are of great global concern, especially when there are no therapeutic interventions available during the time of an outbreak. There are still no therapeutic interventions for the prevention of Zika virus (ZIKV) infections despite its resurgence more than a decade ago. Newborns infected with ZIKV suffer from microcephaly and delayed neurodevelopment, but the underlying causes are largely unknown. All viruses hijack the host cellular machinery to undergo successful replication. Our tandem mass tag mass spectrometry-based proteomic monitoring of cells infected with ZIKV revealed that among the thousands of host proteins dysregulated over time, many protein candidates were linked to neurodevelopmental processes, including the development of the auditory and visual/retinal system. The role of these dysregulated neurodevelopmental-associated host proteins for ZIKV propagation in eukaryotic cells remains elusive. For the first time, we present temporal neurodevelopmental proteomic responses in cells undergoing ZIKV infection. The future goal is to identify host proteins whose dysregulation results in neurosensory alterations reported in children born to ZIKV-infected mothers.https://www.frontiersin.org/article/10.3389/fcell.2020.00571/fullZika virusneurosensory alterationsproteomicsTMT mass spectrometryneurodevelopment |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Kathleen K. M. Glover Kathleen K. M. Glover Ali Zahedi-Amiri Ali Zahedi-Amiri Ying Lao Victor Spicer Thomas Klonisch Thomas Klonisch Thomas Klonisch Kevin M. Coombs Kevin M. Coombs Kevin M. Coombs |
spellingShingle |
Kathleen K. M. Glover Kathleen K. M. Glover Ali Zahedi-Amiri Ali Zahedi-Amiri Ying Lao Victor Spicer Thomas Klonisch Thomas Klonisch Thomas Klonisch Kevin M. Coombs Kevin M. Coombs Kevin M. Coombs Zika Infection Disrupts Proteins Involved in the Neurosensory System Frontiers in Cell and Developmental Biology Zika virus neurosensory alterations proteomics TMT mass spectrometry neurodevelopment |
author_facet |
Kathleen K. M. Glover Kathleen K. M. Glover Ali Zahedi-Amiri Ali Zahedi-Amiri Ying Lao Victor Spicer Thomas Klonisch Thomas Klonisch Thomas Klonisch Kevin M. Coombs Kevin M. Coombs Kevin M. Coombs |
author_sort |
Kathleen K. M. Glover |
title |
Zika Infection Disrupts Proteins Involved in the Neurosensory System |
title_short |
Zika Infection Disrupts Proteins Involved in the Neurosensory System |
title_full |
Zika Infection Disrupts Proteins Involved in the Neurosensory System |
title_fullStr |
Zika Infection Disrupts Proteins Involved in the Neurosensory System |
title_full_unstemmed |
Zika Infection Disrupts Proteins Involved in the Neurosensory System |
title_sort |
zika infection disrupts proteins involved in the neurosensory system |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Cell and Developmental Biology |
issn |
2296-634X |
publishDate |
2020-07-01 |
description |
Newly re-emerging viruses are of great global concern, especially when there are no therapeutic interventions available during the time of an outbreak. There are still no therapeutic interventions for the prevention of Zika virus (ZIKV) infections despite its resurgence more than a decade ago. Newborns infected with ZIKV suffer from microcephaly and delayed neurodevelopment, but the underlying causes are largely unknown. All viruses hijack the host cellular machinery to undergo successful replication. Our tandem mass tag mass spectrometry-based proteomic monitoring of cells infected with ZIKV revealed that among the thousands of host proteins dysregulated over time, many protein candidates were linked to neurodevelopmental processes, including the development of the auditory and visual/retinal system. The role of these dysregulated neurodevelopmental-associated host proteins for ZIKV propagation in eukaryotic cells remains elusive. For the first time, we present temporal neurodevelopmental proteomic responses in cells undergoing ZIKV infection. The future goal is to identify host proteins whose dysregulation results in neurosensory alterations reported in children born to ZIKV-infected mothers. |
topic |
Zika virus neurosensory alterations proteomics TMT mass spectrometry neurodevelopment |
url |
https://www.frontiersin.org/article/10.3389/fcell.2020.00571/full |
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