Leflunomide Induced Drug Rash And Hepatotoxicity
A 57 year old female presented with generalized erythematous scay plaques of 11/2 months duration and jaundice since 1 month. She was on leflunomide since 3 months for chronic rheumatoid arthritis. Investigations revealed positive ANA, rheumatoid factor and negative anti-DsDNA. Bilirubin and liver e...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2004-01-01
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| Series: | Indian Journal of Dermatology |
| Online Access: | http://www.e-ijd.org/article.asp?issn=0019-5154;year=2004;volume=49;issue=3;spage=154;epage=155;aulast=Uppal;type=0 |
| Summary: | A 57 year old female presented with generalized erythematous scay plaques of 11/2 months duration and jaundice since 1 month. She was on leflunomide since 3 months for chronic rheumatoid arthritis. Investigations revealed positive ANA, rheumatoid factor and negative anti-DsDNA. Bilirubin and liver enzymes were markedly raised. Viral markers were negative. Direct immunoflourescence did not show lupus band. A diagnosis of drug induced hepatitis and skin rash was made. She was treated with cholestyramine but she died after ten days of hospitalization. |
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| ISSN: | 0019-5154 1998-3611 |