Introducing Pitt-Hopkins syndrome-associated mutations of TCF4 to Drosophila daughterless

Introducing Pitt-Hopkins syndrome-associated mutations of TCF4 to Drosophila daughterless

Pitt-Hopkins syndrome (PTHS) is caused by haploinsufficiency of Transcription factor 4 (TCF4), one of the three human class I basic helix-loop-helix transcription factors called E-proteins. Drosophila has a single E-protein, Daughterless (Da), homologous to all three mammalian counterparts. Here we...

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Bibliographic Details
Main Authors: Laura Tamberg, Mari Sepp, Tõnis Timmusk, Mari Palgi
Format: Article
Language:English
Published: The Company of Biologists 2015-12-01
Series:Biology Open
Subjects:
Pitt-Hopkins syndrome
Drosophila melanogaster
Intellectual disability
Daughterless
bHLH
Nervous system
Online Access:http://bio.biologists.org/content/4/12/1762

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