The TXA2R rs1131882, P2Y1 rs1371097 and GPIIIa rs2317676 three-loci interactions may increase the risk of carotid stenosis in patients with ischemic stroke
Abstract Background The genetic risk factors for carotid stenosis are not fully understood. The aim of this study is to investigate the relationship between variants in platelet activation-relevant genes and carotid stenosis in patients with ischemic stroke (IS). Methods Eleven variants of platelet...
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doaj-158bcfbac2954ae280673f255efb48db2020-11-25T01:38:07ZengBMCBMC Neurology1471-23772019-03-011911910.1186/s12883-019-1271-0The TXA2R rs1131882, P2Y1 rs1371097 and GPIIIa rs2317676 three-loci interactions may increase the risk of carotid stenosis in patients with ischemic strokeXingyang Yi0Jing Lin1Qiang Zhou2Ruyue Huang3Zhenxiao Chai4Department of Neurology, People’s Hospital of Deyang CityDepartment of Neurology, the Third Affiliated Hospital of Wenzhou Medical UniversityDepartment of Neurology, the Third Affiliated Hospital of Wenzhou Medical UniversityDepartment of Neurology, the Third Affiliated Hospital of Wenzhou Medical UniversityDepartment of Neurology, the Third Affiliated Hospital of Wenzhou Medical UniversityAbstract Background The genetic risk factors for carotid stenosis are not fully understood. The aim of this study is to investigate the relationship between variants in platelet activation-relevant genes and carotid stenosis in patients with ischemic stroke (IS). Methods Eleven variants of platelet activation-relevant genes, aggregates of platelet-leukocyte, and platelet aggregation were examined in 236 IS patients with carotid stenosis and 378 patients without carotid stenosis. High-resolution B-mode ultrasound was used to assess carotid stenosis. Generalized multifactor dimensionality reduction (GMDR) methods were applied in analyzing gene-gene interactions to determine whether there was any interactive role of assessed variants in affecting risk of carotid stenosis. Results Platelet aggregation and aggregates of platelet-leukocyte showed higher value in patients with carotid stenosis, compared with patients without carotid stenosis. Excluding potential disturbance variables, these 11 variants were not associated with carotid stenosis. However, according to the GMDR analysis, gene-gene interactions among TXA2R rs1131882, P2Y1 rs1371097 and GPIIIa rs2317676 had a synergistic influence on carotid stenosis. The high-risk interactions between the three variants showed a relationship with higher platelet activation, and have independent associations with risk of carotid stenosis (OR = 2.72, 95% CI: 1.28–7.82, P = 0.001). Conclusion The interactions among rs1131882, rs1371097 and rs2317676 perhaps increase the risk of symptomatic carotid stenosis, and maybe a potential marker for carotid stenosis. In this study, the combinatorial analysis made good use in elucidating complex risk factors in the heredity of carotid stenosis.http://link.springer.com/article/10.1186/s12883-019-1271-0Carotid atherosclerosisGenetic polymorphismCarotid stenosisPlatelet activationGMDR |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Xingyang Yi Jing Lin Qiang Zhou Ruyue Huang Zhenxiao Chai |
spellingShingle |
Xingyang Yi Jing Lin Qiang Zhou Ruyue Huang Zhenxiao Chai The TXA2R rs1131882, P2Y1 rs1371097 and GPIIIa rs2317676 three-loci interactions may increase the risk of carotid stenosis in patients with ischemic stroke BMC Neurology Carotid atherosclerosis Genetic polymorphism Carotid stenosis Platelet activation GMDR |
author_facet |
Xingyang Yi Jing Lin Qiang Zhou Ruyue Huang Zhenxiao Chai |
author_sort |
Xingyang Yi |
title |
The TXA2R rs1131882, P2Y1 rs1371097 and GPIIIa rs2317676 three-loci interactions may increase the risk of carotid stenosis in patients with ischemic stroke |
title_short |
The TXA2R rs1131882, P2Y1 rs1371097 and GPIIIa rs2317676 three-loci interactions may increase the risk of carotid stenosis in patients with ischemic stroke |
title_full |
The TXA2R rs1131882, P2Y1 rs1371097 and GPIIIa rs2317676 three-loci interactions may increase the risk of carotid stenosis in patients with ischemic stroke |
title_fullStr |
The TXA2R rs1131882, P2Y1 rs1371097 and GPIIIa rs2317676 three-loci interactions may increase the risk of carotid stenosis in patients with ischemic stroke |
title_full_unstemmed |
The TXA2R rs1131882, P2Y1 rs1371097 and GPIIIa rs2317676 three-loci interactions may increase the risk of carotid stenosis in patients with ischemic stroke |
title_sort |
txa2r rs1131882, p2y1 rs1371097 and gpiiia rs2317676 three-loci interactions may increase the risk of carotid stenosis in patients with ischemic stroke |
publisher |
BMC |
series |
BMC Neurology |
issn |
1471-2377 |
publishDate |
2019-03-01 |
description |
Abstract Background The genetic risk factors for carotid stenosis are not fully understood. The aim of this study is to investigate the relationship between variants in platelet activation-relevant genes and carotid stenosis in patients with ischemic stroke (IS). Methods Eleven variants of platelet activation-relevant genes, aggregates of platelet-leukocyte, and platelet aggregation were examined in 236 IS patients with carotid stenosis and 378 patients without carotid stenosis. High-resolution B-mode ultrasound was used to assess carotid stenosis. Generalized multifactor dimensionality reduction (GMDR) methods were applied in analyzing gene-gene interactions to determine whether there was any interactive role of assessed variants in affecting risk of carotid stenosis. Results Platelet aggregation and aggregates of platelet-leukocyte showed higher value in patients with carotid stenosis, compared with patients without carotid stenosis. Excluding potential disturbance variables, these 11 variants were not associated with carotid stenosis. However, according to the GMDR analysis, gene-gene interactions among TXA2R rs1131882, P2Y1 rs1371097 and GPIIIa rs2317676 had a synergistic influence on carotid stenosis. The high-risk interactions between the three variants showed a relationship with higher platelet activation, and have independent associations with risk of carotid stenosis (OR = 2.72, 95% CI: 1.28–7.82, P = 0.001). Conclusion The interactions among rs1131882, rs1371097 and rs2317676 perhaps increase the risk of symptomatic carotid stenosis, and maybe a potential marker for carotid stenosis. In this study, the combinatorial analysis made good use in elucidating complex risk factors in the heredity of carotid stenosis. |
topic |
Carotid atherosclerosis Genetic polymorphism Carotid stenosis Platelet activation GMDR |
url |
http://link.springer.com/article/10.1186/s12883-019-1271-0 |
work_keys_str_mv |
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