Clinical Manifestations and Outcomes of West Nile Virus Infection

Since the emergence of West Nile virus (WNV) in North America in 1999, understanding of the clinical features, spectrum of illness and eventual functional outcomes of human illness has increased tremendously. Most human infections with WNV remain clinically silent. Among those persons developing sym...

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Main Author: James J. Sejvar
Format: Article
Language:English
Published: MDPI AG 2014-02-01
Series:Viruses
Subjects:
Online Access:http://www.mdpi.com/1999-4915/6/2/606
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spelling doaj-158ec00126024e3c88d35ad04b3d03512020-11-24T21:56:40ZengMDPI AGViruses1999-49152014-02-016260662310.3390/v6020606v6020606Clinical Manifestations and Outcomes of West Nile Virus InfectionJames J. Sejvar0National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USASince the emergence of West Nile virus (WNV) in North America in 1999, understanding of the clinical features, spectrum of illness and eventual functional outcomes of human illness has increased tremendously. Most human infections with WNV remain clinically silent. Among those persons developing symptomatic illness, most develop a self-limited febrile illness. More severe illness with WNV (West Nile neuroinvasive disease, WNND) is manifested as meningitis, encephalitis or an acute anterior (polio) myelitis. These manifestations are generally more prevalent in older persons or those with immunosuppression. In the future, a more thorough understanding of the long-term physical, cognitive and functional outcomes of persons recovering from WNV illness will be important in understanding the overall illness burden.http://www.mdpi.com/1999-4915/6/2/606West Nile virusmeningitisencephalitispoliomyelitisoutcomes
collection DOAJ
language English
format Article
sources DOAJ
author James J. Sejvar
spellingShingle James J. Sejvar
Clinical Manifestations and Outcomes of West Nile Virus Infection
Viruses
West Nile virus
meningitis
encephalitis
poliomyelitis
outcomes
author_facet James J. Sejvar
author_sort James J. Sejvar
title Clinical Manifestations and Outcomes of West Nile Virus Infection
title_short Clinical Manifestations and Outcomes of West Nile Virus Infection
title_full Clinical Manifestations and Outcomes of West Nile Virus Infection
title_fullStr Clinical Manifestations and Outcomes of West Nile Virus Infection
title_full_unstemmed Clinical Manifestations and Outcomes of West Nile Virus Infection
title_sort clinical manifestations and outcomes of west nile virus infection
publisher MDPI AG
series Viruses
issn 1999-4915
publishDate 2014-02-01
description Since the emergence of West Nile virus (WNV) in North America in 1999, understanding of the clinical features, spectrum of illness and eventual functional outcomes of human illness has increased tremendously. Most human infections with WNV remain clinically silent. Among those persons developing symptomatic illness, most develop a self-limited febrile illness. More severe illness with WNV (West Nile neuroinvasive disease, WNND) is manifested as meningitis, encephalitis or an acute anterior (polio) myelitis. These manifestations are generally more prevalent in older persons or those with immunosuppression. In the future, a more thorough understanding of the long-term physical, cognitive and functional outcomes of persons recovering from WNV illness will be important in understanding the overall illness burden.
topic West Nile virus
meningitis
encephalitis
poliomyelitis
outcomes
url http://www.mdpi.com/1999-4915/6/2/606
work_keys_str_mv AT jamesjsejvar clinicalmanifestationsandoutcomesofwestnilevirusinfection
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