Epigenetic Regulators in the Development, Maintenance, and Therapeutic Targeting of Acute Myeloid Leukemia

Epigenetic Regulators in the Development, Maintenance, and Therapeutic Targeting of Acute Myeloid Leukemia

The importance of epigenetic dysregulation to acute myeloid leukemia (AML) pathophysiology has become increasingly apparent in recent years. Epigenetic regulators, including readers, writers, and erasers, are recurrently dysregulated by way of chromosomal translocations, somatic mutations, or genomi...

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Bibliographic Details
Main Authors: Younguk Sun, Bo-Rui Chen, Aniruddha Deshpande
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-02-01
Series:Frontiers in Oncology
Subjects:
acute myeloid leukemia
epigenetic therapy
leukemia stem cell
epigenome
chromatin modification
Online Access:http://journal.frontiersin.org/article/10.3389/fonc.2018.00041/full

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