Accumulation of wildtype and ALS-linked mutated VAPB impairs activity of the proteasome.
Cellular homeostasis relies on a tight control of protein synthesis, folding and degradation, in which the endoplasmic reticulum (ER) quality control and the ubiquitin proteasome system (UPS) have an instrumental function. ER stress and aberrant accumulation of misfolded proteins represent a patholo...
Main Authors: | Anice Moumen, Isabelle Virard, Cédric Raoul |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2011-01-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC3187839?pdf=render |
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