Maternal inflammation leads to impaired glutamate homeostasis and up-regulation of glutamate carboxypeptidase II in activated microglia in the fetal/newborn rabbit brain

Maternal inflammation leads to impaired glutamate homeostasis and up-regulation of glutamate carboxypeptidase II in activated microglia in the fetal/newborn rabbit brain

Astrocyte dysfunction and excessive activation of glutamatergic systems have been implicated in a number of neurologic disorders, including periventricular leukomalacia (PVL) and cerebral palsy (CP). However, the role of chorioamnionitis on glutamate homeostasis in the fetal and neonatal brains is n...

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Bibliographic Details
Main Authors: Zhi Zhang, Bassam Bassam, Ajit G. Thomas, Monica Williams, Jinhuan Liu, Elizabeth Nance, Camilo Rojas, Barbara S. Slusher, Sujatha Kannan
Format: Article
Language:English
Published: Elsevier 2016-10-01
Series:Neurobiology of Disease
Subjects:
Cerebral palsy
Periventricular leukomalacia
Glutamate
Glutamate carboxypeptidase II (GCPII)
Microglia
Astrocytes
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996116301437

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