Genome-Wide Maps of m6A circRNAs Identify Widespread and Cell-Type-Specific Methylation Patterns that Are Distinct from mRNAs

Genome-Wide Maps of m6A circRNAs Identify Widespread and Cell-Type-Specific Methylation Patterns that Are Distinct from mRNAs

N6-methyladenosine (m6A) is the most abundant internal modification of mRNAs and is implicated in all aspects of post-transcriptional RNA metabolism. However, little is known about m6A modifications to circular (circ) RNAs. We developed a computational pipeline (AutoCirc) that, together with depleti...

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Bibliographic Details
Main Authors: Chan Zhou, Benoit Molinie, Kaveh Daneshvar, Joshua V. Pondick, Jinkai Wang, Nicholas Van Wittenberghe, Yi Xing, Cosmas C. Giallourakis, Alan C. Mullen
Format: Article
Language:English
Published: Elsevier 2017-08-01
Series:Cell Reports
Subjects:
circular RNAs
m6A modification
noncoding RNAs
embryonic stem cells
METTL3
YTHDF2
methyladenosine
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717311348

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