Evaluation of liver diseases in Iranian patients with primary antibody deficiencies
Introduction. Patients with primary antibody deficiency (PAD) can complicate with liver disease. This study was performed in order to study the prevalence and causes of hepatobiliary diseases in Iranian patients with PAD.Material and methods. Sixty-two patients with PAD were followed-up and signs an...
Main Authors: | , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2009-07-01
|
Series: | Annals of Hepatology |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S166526811931765X |
id |
doaj-15a3da2659884772b30ee0b567888399 |
---|---|
record_format |
Article |
spelling |
doaj-15a3da2659884772b30ee0b5678883992021-06-09T05:55:49ZengElsevierAnnals of Hepatology1665-26812009-07-0183196202Evaluation of liver diseases in Iranian patients with primary antibody deficienciesFarzaneh Motamed0Asghar Aghamohammadi1Mahmoud Soltani2Mahboubeh Mansouri3Nima Rezaei4Shahram Teimourian5Nima Pouladi6Sina Abdollahzadeh7Nima Parvaneh8Pediatrics Center of Excellence, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran.Pediatrics Center of Excellence, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran.; Growth and Development Research Center, Tehran University of Medical Sciences, Tehran, Iran.; Correspondence and reprint requestPediatrics Center of Excellence, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran.Mofid Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Pediatrics Center of Excellence, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran.; Growth and Development Research Center, Tehran University of Medical Sciences, Tehran, Iran.Growth and Development Research Center, Tehran University of Medical Sciences, Tehran, Iran.; Pasteur Institute of Iran, Tehran, Iran.Growth and Development Research Center, Tehran University of Medical Sciences, Tehran, Iran.Students’ Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran.Pediatrics Center of Excellence, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran.; Growth and Development Research Center, Tehran University of Medical Sciences, Tehran, Iran.Introduction. Patients with primary antibody deficiency (PAD) can complicate with liver disease. This study was performed in order to study the prevalence and causes of hepatobiliary diseases in Iranian patients with PAD.Material and methods. Sixty-two patients with PAD were followed-up and signs and symptoms of liver disease were recorded. All patients were screened for hepatitis C virus (HCV-RNA) and those patients with any sign of liver disease or gastrointestinal complaints were tested for Cryptosporidium parvum.Results. Clinical evidences of liver disease, including hepatomegaly, were documented in 22 patients (35.5%). Eight patients (13%) had clinical and/or laboratory criteria of chronic liver disease. Only one patient was HCV-RNA positive; he had stigmata of chronic liver disease and pathologic evidence of chronic active hepatitis with cirrhosis. Cryptosporidium parvum test was positive for one patient with hyper-IgM syndrome. In liver biopsy of patients with liver involvement, one had histological findings related to sclerosing cholangitis, and five had mild to moderate chronic active hepatitis with unknown reason.Conclusions. Chronic active hepatitis is the most common pathologic feature of liver injury in Iranian patients with PAD. Liver disease in PAD usually accompanies with other organ involvements and could increase the mortality of PAD. Whether this high rate of liver disease with unknown origin (75%) is the result of an unidentified hepatotropic virus or other mechanisms such as autoimmunity, is currently difficult to understand.http://www.sciencedirect.com/science/article/pii/S166526811931765XLiver diseasePrimary antibody deficiencyHCV infectionChronic active hepatitis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Farzaneh Motamed Asghar Aghamohammadi Mahmoud Soltani Mahboubeh Mansouri Nima Rezaei Shahram Teimourian Nima Pouladi Sina Abdollahzadeh Nima Parvaneh |
spellingShingle |
Farzaneh Motamed Asghar Aghamohammadi Mahmoud Soltani Mahboubeh Mansouri Nima Rezaei Shahram Teimourian Nima Pouladi Sina Abdollahzadeh Nima Parvaneh Evaluation of liver diseases in Iranian patients with primary antibody deficiencies Annals of Hepatology Liver disease Primary antibody deficiency HCV infection Chronic active hepatitis |
author_facet |
Farzaneh Motamed Asghar Aghamohammadi Mahmoud Soltani Mahboubeh Mansouri Nima Rezaei Shahram Teimourian Nima Pouladi Sina Abdollahzadeh Nima Parvaneh |
author_sort |
Farzaneh Motamed |
title |
Evaluation of liver diseases in Iranian patients with primary antibody deficiencies |
title_short |
Evaluation of liver diseases in Iranian patients with primary antibody deficiencies |
title_full |
Evaluation of liver diseases in Iranian patients with primary antibody deficiencies |
title_fullStr |
Evaluation of liver diseases in Iranian patients with primary antibody deficiencies |
title_full_unstemmed |
Evaluation of liver diseases in Iranian patients with primary antibody deficiencies |
title_sort |
evaluation of liver diseases in iranian patients with primary antibody deficiencies |
publisher |
Elsevier |
series |
Annals of Hepatology |
issn |
1665-2681 |
publishDate |
2009-07-01 |
description |
Introduction. Patients with primary antibody deficiency (PAD) can complicate with liver disease. This study was performed in order to study the prevalence and causes of hepatobiliary diseases in Iranian patients with PAD.Material and methods. Sixty-two patients with PAD were followed-up and signs and symptoms of liver disease were recorded. All patients were screened for hepatitis C virus (HCV-RNA) and those patients with any sign of liver disease or gastrointestinal complaints were tested for Cryptosporidium parvum.Results. Clinical evidences of liver disease, including hepatomegaly, were documented in 22 patients (35.5%). Eight patients (13%) had clinical and/or laboratory criteria of chronic liver disease. Only one patient was HCV-RNA positive; he had stigmata of chronic liver disease and pathologic evidence of chronic active hepatitis with cirrhosis. Cryptosporidium parvum test was positive for one patient with hyper-IgM syndrome. In liver biopsy of patients with liver involvement, one had histological findings related to sclerosing cholangitis, and five had mild to moderate chronic active hepatitis with unknown reason.Conclusions. Chronic active hepatitis is the most common pathologic feature of liver injury in Iranian patients with PAD. Liver disease in PAD usually accompanies with other organ involvements and could increase the mortality of PAD. Whether this high rate of liver disease with unknown origin (75%) is the result of an unidentified hepatotropic virus or other mechanisms such as autoimmunity, is currently difficult to understand. |
topic |
Liver disease Primary antibody deficiency HCV infection Chronic active hepatitis |
url |
http://www.sciencedirect.com/science/article/pii/S166526811931765X |
work_keys_str_mv |
AT farzanehmotamed evaluationofliverdiseasesiniranianpatientswithprimaryantibodydeficiencies AT asgharaghamohammadi evaluationofliverdiseasesiniranianpatientswithprimaryantibodydeficiencies AT mahmoudsoltani evaluationofliverdiseasesiniranianpatientswithprimaryantibodydeficiencies AT mahboubehmansouri evaluationofliverdiseasesiniranianpatientswithprimaryantibodydeficiencies AT nimarezaei evaluationofliverdiseasesiniranianpatientswithprimaryantibodydeficiencies AT shahramteimourian evaluationofliverdiseasesiniranianpatientswithprimaryantibodydeficiencies AT nimapouladi evaluationofliverdiseasesiniranianpatientswithprimaryantibodydeficiencies AT sinaabdollahzadeh evaluationofliverdiseasesiniranianpatientswithprimaryantibodydeficiencies AT nimaparvaneh evaluationofliverdiseasesiniranianpatientswithprimaryantibodydeficiencies |
_version_ |
1721388540337586176 |