A Single-Stranded Oligonucleotide Inhibits Toll-Like Receptor 3 Activation and Reduces Influenza A (H1N1) Infection

A Single-Stranded Oligonucleotide Inhibits Toll-Like Receptor 3 Activation and Reduces Influenza A (H1N1) Infection

The initiation of an immune response is dependent on the activation and maturation of dendritic cells after sensing pathogen associated molecular patterns by pattern recognition receptors. However, the response needs to be balanced as excessive pro-inflammatory cytokine production in response to vir...

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Bibliographic Details
Main Authors: Candice Poux, Aleksandra Dondalska, Joseph Bergenstråhle, Sandra Pålsson, Vanessa Contreras, Claudia Arasa, Peter Järver, Jan Albert, David C. Busse, Roger LeGrand, Joakim Lundeberg, John S. Tregoning, Anna-Lena Spetz
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Immunology
Subjects:
influenza A
TLR3
single-stranded oligonucleotides
human monocyte-derived dendritic cells (MoDC)
mice
cytokines
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02161/full

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