Dipeptidyl Peptidase IV as a Muscle Myokine
Dipeptidyl peptidase IV (DPP-IV) is a unique serine protease that exists in a membrane bound state and in a soluble state in most tissues in the body. DPP-IV has multiple targets including cytokines, neuropeptides, and incretin hormones, and plays an important role in health and disease. Recent work...
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Frontiers Media S.A.
2020-03-01
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| Series: | Frontiers in Physiology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fphys.2020.00148/full |
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doaj-15b493055431424e84c30238c6206da22020-11-25T00:34:56ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2020-03-011110.3389/fphys.2020.00148475835Dipeptidyl Peptidase IV as a Muscle MyokineHeidi A. KluessDipeptidyl peptidase IV (DPP-IV) is a unique serine protease that exists in a membrane bound state and in a soluble state in most tissues in the body. DPP-IV has multiple targets including cytokines, neuropeptides, and incretin hormones, and plays an important role in health and disease. Recent work suggests that skeletal muscle releases DPP-IV as a myokine and participates in control of muscle blood flow. However, few of the functions of DPP-IV as a myokine have been investigated to date and there is a poor understanding about what causes DPP-IV to be released from muscle.https://www.frontiersin.org/article/10.3389/fphys.2020.00148/fullpeptidasemusclesecretomeexercisewhey proteinmetalloproteases |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Heidi A. Kluess |
| spellingShingle |
Heidi A. Kluess Dipeptidyl Peptidase IV as a Muscle Myokine Frontiers in Physiology peptidase muscle secretome exercise whey protein metalloproteases |
| author_facet |
Heidi A. Kluess |
| author_sort |
Heidi A. Kluess |
| title |
Dipeptidyl Peptidase IV as a Muscle Myokine |
| title_short |
Dipeptidyl Peptidase IV as a Muscle Myokine |
| title_full |
Dipeptidyl Peptidase IV as a Muscle Myokine |
| title_fullStr |
Dipeptidyl Peptidase IV as a Muscle Myokine |
| title_full_unstemmed |
Dipeptidyl Peptidase IV as a Muscle Myokine |
| title_sort |
dipeptidyl peptidase iv as a muscle myokine |
| publisher |
Frontiers Media S.A. |
| series |
Frontiers in Physiology |
| issn |
1664-042X |
| publishDate |
2020-03-01 |
| description |
Dipeptidyl peptidase IV (DPP-IV) is a unique serine protease that exists in a membrane bound state and in a soluble state in most tissues in the body. DPP-IV has multiple targets including cytokines, neuropeptides, and incretin hormones, and plays an important role in health and disease. Recent work suggests that skeletal muscle releases DPP-IV as a myokine and participates in control of muscle blood flow. However, few of the functions of DPP-IV as a myokine have been investigated to date and there is a poor understanding about what causes DPP-IV to be released from muscle. |
| topic |
peptidase muscle secretome exercise whey protein metalloproteases |
| url |
https://www.frontiersin.org/article/10.3389/fphys.2020.00148/full |
| work_keys_str_mv |
AT heidiakluess dipeptidylpeptidaseivasamusclemyokine |
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