Host-parasite co-metabolic activation of antitrypanosomal aminomethyl-benzoxaboroles.

Host-parasite co-metabolic activation of antitrypanosomal aminomethyl-benzoxaboroles.

Recent development of benzoxaborole-based chemistry gave rise to a collection of compounds with great potential in targeting diverse infectious diseases, including human African Trypanosomiasis (HAT), a devastating neglected tropical disease. However, further medicinal development is largely restric...

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Bibliographic Details
Main Authors: Ning Zhang, Martin Zoltner, Ka-Fai Leung, Paul Scullion, Sebastian Hutchinson, Ricardo C Del Pino, Isabel M Vincent, Yong-Kang Zhang, Yvonne R Freund, Michael R K Alley, Robert T Jacobs, Kevin D Read, Michael P Barrett, David Horn, Mark C Field
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-02-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1006850

Internet

https://doi.org/10.1371/journal.ppat.1006850

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