Transfusion of Red Blood Cells to Patients with Sepsis
Sepsis is one of the major causes of death worldwide, and is the host response to infection which renders our organs malfunctioning. Insufficient tissue perfusion and oxygen delivery have been implicated in the pathogenesis of sepsis-related organ dysfunction, making transfusion of packed red blood...
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doaj-15bc682f79264f228da81ceb0d51e8222020-11-24T20:47:11ZengMDPI AGInternational Journal of Molecular Sciences1422-00672017-09-01189194610.3390/ijms18091946ijms18091946Transfusion of Red Blood Cells to Patients with SepsisYi-Ling Chan0Shih-Tsung Han1Chih-Huang Li2Chin-Chieh Wu3Kuan-Fu Chen4Department of Emergency Medicine, Chang Gung Memorial Hospital Linkou, Taoyuan 330, TaiwanDepartment of Emergency Medicine, Chang Gung Memorial Hospital Linkou, Taoyuan 330, TaiwanDepartment of Emergency Medicine, Chang Gung Memorial Hospital Linkou, Taoyuan 330, TaiwanDepartment of Emergency Medicine, Chang Gung Memorial Hospital Keelung, Keelung 204, TaiwanDepartment of Emergency Medicine, Chang Gung Memorial Hospital Linkou, Taoyuan 330, TaiwanSepsis is one of the major causes of death worldwide, and is the host response to infection which renders our organs malfunctioning. Insufficient tissue perfusion and oxygen delivery have been implicated in the pathogenesis of sepsis-related organ dysfunction, making transfusion of packed red blood cells (pRBCs) a reasonable treatment modality. However, clinical trials have generated controversial results. Even the notion that transfused pRBCs increase the oxygen-carrying capacity of blood has been challenged. Meanwhile, during sepsis, the ability of our tissues to utilize oxygen may also be reduced, and the increased blood concentrations of lactate may be the results of strong inflammation and excessive catecholamine release, rather than impaired cell respiration. Leukodepleted pRBCs more consistently demonstrated improvement in microcirculation, and the increase in blood viscosity brought about by pRBC transfusion helps maintain functional capillary density. A restrictive strategy of pRBC transfusion is recommended in treating septic patients.https://www.mdpi.com/1422-0067/18/9/1946sepsistransfusionred blood cells |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yi-Ling Chan Shih-Tsung Han Chih-Huang Li Chin-Chieh Wu Kuan-Fu Chen |
spellingShingle |
Yi-Ling Chan Shih-Tsung Han Chih-Huang Li Chin-Chieh Wu Kuan-Fu Chen Transfusion of Red Blood Cells to Patients with Sepsis International Journal of Molecular Sciences sepsis transfusion red blood cells |
author_facet |
Yi-Ling Chan Shih-Tsung Han Chih-Huang Li Chin-Chieh Wu Kuan-Fu Chen |
author_sort |
Yi-Ling Chan |
title |
Transfusion of Red Blood Cells to Patients with Sepsis |
title_short |
Transfusion of Red Blood Cells to Patients with Sepsis |
title_full |
Transfusion of Red Blood Cells to Patients with Sepsis |
title_fullStr |
Transfusion of Red Blood Cells to Patients with Sepsis |
title_full_unstemmed |
Transfusion of Red Blood Cells to Patients with Sepsis |
title_sort |
transfusion of red blood cells to patients with sepsis |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1422-0067 |
publishDate |
2017-09-01 |
description |
Sepsis is one of the major causes of death worldwide, and is the host response to infection which renders our organs malfunctioning. Insufficient tissue perfusion and oxygen delivery have been implicated in the pathogenesis of sepsis-related organ dysfunction, making transfusion of packed red blood cells (pRBCs) a reasonable treatment modality. However, clinical trials have generated controversial results. Even the notion that transfused pRBCs increase the oxygen-carrying capacity of blood has been challenged. Meanwhile, during sepsis, the ability of our tissues to utilize oxygen may also be reduced, and the increased blood concentrations of lactate may be the results of strong inflammation and excessive catecholamine release, rather than impaired cell respiration. Leukodepleted pRBCs more consistently demonstrated improvement in microcirculation, and the increase in blood viscosity brought about by pRBC transfusion helps maintain functional capillary density. A restrictive strategy of pRBC transfusion is recommended in treating septic patients. |
topic |
sepsis transfusion red blood cells |
url |
https://www.mdpi.com/1422-0067/18/9/1946 |
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