Prediction of Clinically Relevant Safety Signals of Nephrotoxicity through Plasma Metabolite Profiling

Prediction of Clinically Relevant Safety Signals of Nephrotoxicity through Plasma Metabolite Profiling

Addressing safety concerns such as drug-induced kidney injury (DIKI) early in the drug pharmaceutical development process ensures both patient safety and efficient clinical development. We describe a unique adjunct to standard safety assessment wherein the metabolite profile of treated animals is co...

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Bibliographic Details
Main Authors: W. B. Mattes, H. G. Kamp, E. Fabian, M. Herold, G. Krennrich, R. Looser, W. Mellert, A. Prokoudine, V. Strauss, B. van Ravenzwaay, T. Walk, H. Naraoka, K. Omura, I. Schuppe-Koistinen, S. Nadanaciva, E. D. Bush, N. Moeller, P. Ruiz-Noppinger, S. P. Piccoli
Format: Article
Language:English
Published: Hindawi Limited 2013-01-01
Series:BioMed Research International
Online Access:http://dx.doi.org/10.1155/2013/202497

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