Neutrons in studies of phospholipid bilayers and bilayer–drug interaction. I. Basic principles and neutron diffraction

Neutrons in studies of phospholipid bilayers and bilayer–drug interaction. I. Basic principles and neutron diffraction

In our paper, we demonstrate several possibilities of using neutrons in pharmaceutical research with the help of examples of scientific results achieved at our University. In this first part, basic properties of neutrons and elementary principles of elastic scattering of thermal neutrons are describ...

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Bibliographic Details
Main Authors: Belička M., Devínsky F., Balgavý P.
Format: Article
Language:English
Published: Sciendo 2014-12-01
Series:Acta Facultatis Pharmaceuticae Universitatis Comenianae
Subjects:
neutron diffraction
phospholipid bilayer
local anaesthetic
alkan-1-ols
cholesterol
Online Access:https://doi.org/10.2478/afpuc-2014-0010
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spelling doaj-15c4a6277f4e4031b4b480f63009ae2e2021-09-06T19:41:03ZengSciendoActa Facultatis Pharmaceuticae Universitatis Comenianae1338-67862014-12-0161211110.2478/afpuc-2014-0010afpuc-2014-0010Neutrons in studies of phospholipid bilayers and bilayer–drug interaction. I. Basic principles and neutron diffractionBelička M.0Devínsky F.1Balgavý P.2Comenius University in Bratislava, Faculty of Mathematics, Physics and Informatics, Department of Nuclear Physics and Biophysics, Slovak republicComenius University in Bratislava, Faculty of Pharmacy, Department of Chemical Theory of Drugs, Slovak republicComenius University in Bratislava, Faculty of Mathematics, Physics and Informatics, Department of Nuclear Physics and Biophysics, Slovak republicIn our paper, we demonstrate several possibilities of using neutrons in pharmaceutical research with the help of examples of scientific results achieved at our University. In this first part, basic properties of neutrons and elementary principles of elastic scattering of thermal neutrons are described. Results of contrast variation neutron diffraction on oriented phospholipid bilayers with intercalated local anaesthetic or cholesterol demonstrate the potential of this method at determination of their position in bilayers. Diffraction experiments with alkan-1-ols located in the bilayers revealed their influence on bilayer thickness as a function of their alkyl chain length.https://doi.org/10.2478/afpuc-2014-0010neutron diffractionphospholipid bilayerlocal anaesthetic alkan-1-ols cholesterol
collection DOAJ
language English
format Article
sources DOAJ
author Belička M.
Devínsky F.
Balgavý P.
spellingShingle Belička M.
Devínsky F.
Balgavý P.
Neutrons in studies of phospholipid bilayers and bilayer–drug interaction. I. Basic principles and neutron diffraction
Acta Facultatis Pharmaceuticae Universitatis Comenianae
neutron diffraction
phospholipid bilayer
local anaesthetic
alkan-1-ols
cholesterol
author_facet Belička M.
Devínsky F.
Balgavý P.
author_sort Belička M.
title Neutrons in studies of phospholipid bilayers and bilayer–drug interaction. I. Basic principles and neutron diffraction
title_short Neutrons in studies of phospholipid bilayers and bilayer–drug interaction. I. Basic principles and neutron diffraction
title_full Neutrons in studies of phospholipid bilayers and bilayer–drug interaction. I. Basic principles and neutron diffraction
title_fullStr Neutrons in studies of phospholipid bilayers and bilayer–drug interaction. I. Basic principles and neutron diffraction
title_full_unstemmed Neutrons in studies of phospholipid bilayers and bilayer–drug interaction. I. Basic principles and neutron diffraction
title_sort neutrons in studies of phospholipid bilayers and bilayer–drug interaction. i. basic principles and neutron diffraction
publisher Sciendo
series Acta Facultatis Pharmaceuticae Universitatis Comenianae
issn 1338-6786
publishDate 2014-12-01
description In our paper, we demonstrate several possibilities of using neutrons in pharmaceutical research with the help of examples of scientific results achieved at our University. In this first part, basic properties of neutrons and elementary principles of elastic scattering of thermal neutrons are described. Results of contrast variation neutron diffraction on oriented phospholipid bilayers with intercalated local anaesthetic or cholesterol demonstrate the potential of this method at determination of their position in bilayers. Diffraction experiments with alkan-1-ols located in the bilayers revealed their influence on bilayer thickness as a function of their alkyl chain length.
topic neutron diffraction
phospholipid bilayer
local anaesthetic
alkan-1-ols
cholesterol
url https://doi.org/10.2478/afpuc-2014-0010
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AT devinskyf neutronsinstudiesofphospholipidbilayersandbilayerdruginteractionibasicprinciplesandneutrondiffraction
AT balgavyp neutronsinstudiesofphospholipidbilayersandbilayerdruginteractionibasicprinciplesandneutrondiffraction
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