Efficacy and Safety of Traditional Chinese Medicine in the Treatment of Immune Infertility Based on the Theory of “Kidney Deficiency and Blood Stasis”: A Systematic Review and Meta-Analysis
Objective. This study aims to evaluate the efficacy and safety of traditional Chinese medicine (TCM) therapy of tonifying kidney and activating blood circulation (TKABC) based on the theory of “kidney deficiency and blood stasis” for the treatment of immune infertility. Methods. Six electronic datab...
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doaj-15c9d44e9a224b6b974755f1d188d5db2021-05-31T00:32:43ZengHindawi LimitedEvidence-Based Complementary and Alternative Medicine1741-42882021-01-01202110.1155/2021/9947348Efficacy and Safety of Traditional Chinese Medicine in the Treatment of Immune Infertility Based on the Theory of “Kidney Deficiency and Blood Stasis”: A Systematic Review and Meta-AnalysisYi-ling Bai0Yun-hui Chen1Cui Jiang2Jun-hui Qian3Ling-ling Han4Hai-zhen Lu5Hao-zhong Wang6Yi-rong Sun7College of Basic MedicineCollege of Basic MedicineCollege of Basic MedicineHospital of Chengdu University of Traditional Chinese MedicineCollege of Basic MedicineCollege of Basic MedicineCollege of Basic MedicineGuangzhou Institutes of Biomedicine and HealthObjective. This study aims to evaluate the efficacy and safety of traditional Chinese medicine (TCM) therapy of tonifying kidney and activating blood circulation (TKABC) based on the theory of “kidney deficiency and blood stasis” for the treatment of immune infertility. Methods. Six electronic databases, including the Cochrane Library, PubMed, EMBASE, the China National Knowledge Infrastructure, Wanfang Data, and VIP information database, were searched from inception to January 2021 to identify eligible studies of randomized controlled trials (RCTs). The primary outcome measurements were the total effective rate and pregnancy rate, and the secondary outcome measurements included the negative conversion rate of serum antibodies and the incidence of adverse effects. The quantitative synthesis was performed using the Review Manager 5.3 software. The chi-square statistic and I2 statistic were employed to investigate statistical heterogeneity. The fixed-effects model was used for a low heterogeneity (I2 < 50%), and the random-effects model was applied if heterogeneity was moderate (50% < I2 < 75%). Funnel plots were used to evaluate potential reporting bias when more than ten eligible studies were included. Results. Thirteen RCTs involving 1298 patients with immune infertility of kidney deficiency and blood stasis were included. Compared with conventional group, TCM TKABC therapy showed a significant improvement on the total effective rate (RR: 1.38; 95% CI: 1.30,1.47; and I2 = 0%), pregnancy rate (RR: 2.04; 95% CI: 1.73, 2.40; and I2 = 30%), negative conversion rates of AsAb (RR: 1.42; 95% CI: 1.12,1.79; and I2 = 62%), AEmAb rates (RR: 1.21; 95% CI: 1.04,1.41; and I2 = 0%), and AhCGAb with less adverse effects (RR: 0.24; 95% CI: 1.73, 2.40; and I2 = 55%). However, the negative conversion rate of AoAb and ACAb showed no significant statistical difference. Conclusions. Our review suggests that TCM TKABC therapy based on the theory of kidney deficiency and blood stasis appears to be an effective and safe approach for patients with immune infertility. However, the methodological quality of included RCTs was unsatisfactory, and it is necessary to verify its effectiveness with more well-designed and high-quality multicenter RCTs.http://dx.doi.org/10.1155/2021/9947348 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yi-ling Bai Yun-hui Chen Cui Jiang Jun-hui Qian Ling-ling Han Hai-zhen Lu Hao-zhong Wang Yi-rong Sun |
spellingShingle |
Yi-ling Bai Yun-hui Chen Cui Jiang Jun-hui Qian Ling-ling Han Hai-zhen Lu Hao-zhong Wang Yi-rong Sun Efficacy and Safety of Traditional Chinese Medicine in the Treatment of Immune Infertility Based on the Theory of “Kidney Deficiency and Blood Stasis”: A Systematic Review and Meta-Analysis Evidence-Based Complementary and Alternative Medicine |
author_facet |
Yi-ling Bai Yun-hui Chen Cui Jiang Jun-hui Qian Ling-ling Han Hai-zhen Lu Hao-zhong Wang Yi-rong Sun |
author_sort |
Yi-ling Bai |
title |
Efficacy and Safety of Traditional Chinese Medicine in the Treatment of Immune Infertility Based on the Theory of “Kidney Deficiency and Blood Stasis”: A Systematic Review and Meta-Analysis |
title_short |
Efficacy and Safety of Traditional Chinese Medicine in the Treatment of Immune Infertility Based on the Theory of “Kidney Deficiency and Blood Stasis”: A Systematic Review and Meta-Analysis |
title_full |
Efficacy and Safety of Traditional Chinese Medicine in the Treatment of Immune Infertility Based on the Theory of “Kidney Deficiency and Blood Stasis”: A Systematic Review and Meta-Analysis |
title_fullStr |
Efficacy and Safety of Traditional Chinese Medicine in the Treatment of Immune Infertility Based on the Theory of “Kidney Deficiency and Blood Stasis”: A Systematic Review and Meta-Analysis |
title_full_unstemmed |
Efficacy and Safety of Traditional Chinese Medicine in the Treatment of Immune Infertility Based on the Theory of “Kidney Deficiency and Blood Stasis”: A Systematic Review and Meta-Analysis |
title_sort |
efficacy and safety of traditional chinese medicine in the treatment of immune infertility based on the theory of “kidney deficiency and blood stasis”: a systematic review and meta-analysis |
publisher |
Hindawi Limited |
series |
Evidence-Based Complementary and Alternative Medicine |
issn |
1741-4288 |
publishDate |
2021-01-01 |
description |
Objective. This study aims to evaluate the efficacy and safety of traditional Chinese medicine (TCM) therapy of tonifying kidney and activating blood circulation (TKABC) based on the theory of “kidney deficiency and blood stasis” for the treatment of immune infertility. Methods. Six electronic databases, including the Cochrane Library, PubMed, EMBASE, the China National Knowledge Infrastructure, Wanfang Data, and VIP information database, were searched from inception to January 2021 to identify eligible studies of randomized controlled trials (RCTs). The primary outcome measurements were the total effective rate and pregnancy rate, and the secondary outcome measurements included the negative conversion rate of serum antibodies and the incidence of adverse effects. The quantitative synthesis was performed using the Review Manager 5.3 software. The chi-square statistic and I2 statistic were employed to investigate statistical heterogeneity. The fixed-effects model was used for a low heterogeneity (I2 < 50%), and the random-effects model was applied if heterogeneity was moderate (50% < I2 < 75%). Funnel plots were used to evaluate potential reporting bias when more than ten eligible studies were included. Results. Thirteen RCTs involving 1298 patients with immune infertility of kidney deficiency and blood stasis were included. Compared with conventional group, TCM TKABC therapy showed a significant improvement on the total effective rate (RR: 1.38; 95% CI: 1.30,1.47; and I2 = 0%), pregnancy rate (RR: 2.04; 95% CI: 1.73, 2.40; and I2 = 30%), negative conversion rates of AsAb (RR: 1.42; 95% CI: 1.12,1.79; and I2 = 62%), AEmAb rates (RR: 1.21; 95% CI: 1.04,1.41; and I2 = 0%), and AhCGAb with less adverse effects (RR: 0.24; 95% CI: 1.73, 2.40; and I2 = 55%). However, the negative conversion rate of AoAb and ACAb showed no significant statistical difference. Conclusions. Our review suggests that TCM TKABC therapy based on the theory of kidney deficiency and blood stasis appears to be an effective and safe approach for patients with immune infertility. However, the methodological quality of included RCTs was unsatisfactory, and it is necessary to verify its effectiveness with more well-designed and high-quality multicenter RCTs. |
url |
http://dx.doi.org/10.1155/2021/9947348 |
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