Albumin-bioinspired iridium oxide nanoplatform with high photothermal conversion efficiency for synergistic chemo-photothermal of osteosarcoma
Protein-based nanocarriers with inherent biocompatibility have been widely served as building blocks to construct versatile therapeutic nanoplatforms. Herein, bovine serum albumin-iridium oxide nanoparticles (denoted BSA-IrO2 NPs) are successfully synthesized via one-step biomineralization approach....
Main Authors: | , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Taylor & Francis Group
2019-01-01
|
Series: | Drug Delivery |
Subjects: | |
Online Access: | http://dx.doi.org/10.1080/10717544.2019.1662513 |
id |
doaj-15cd6bb4b3534ee9a334856a9eac21ad |
---|---|
record_format |
Article |
spelling |
doaj-15cd6bb4b3534ee9a334856a9eac21ad2020-11-25T01:10:23ZengTaylor & Francis GroupDrug Delivery1071-75441521-04642019-01-0126191892710.1080/10717544.2019.16625131662513Albumin-bioinspired iridium oxide nanoplatform with high photothermal conversion efficiency for synergistic chemo-photothermal of osteosarcomaWenguang Gu0Tao Zhang1Junsheng Gao2Yi Wang3Dejian Li4Ziwen Zhao5Bo Jiang6Zhiwei Dong7Hui Liu8The First Affiliated Hospital of Harbin Medical UniversityThe First Affiliated Hospital of Harbin Medical UniversityThe First Affiliated Hospital of Harbin Medical UniversityThe First Affiliated Hospital of Harbin Medical UniversityShanghai Pudong Hospital, Fudan University Pudong Medical CenterThe First Affiliated Hospital of Harbin Medical UniversityThe First Affiliated Hospital of Harbin Medical UniversityThe First Affiliated Hospital of Harbin Medical UniversityThe First Affiliated Hospital of Harbin Medical UniversityProtein-based nanocarriers with inherent biocompatibility have been widely served as building blocks to construct versatile therapeutic nanoplatforms. Herein, bovine serum albumin-iridium oxide nanoparticles (denoted BSA-IrO2 NPs) are successfully synthesized via one-step biomineralization approach. The BSA-IrO2 NPs exhibits uniform size (40 nm), superb biocompatibility and high drug loading capacity for doxorubicin (27.4 wt%). Under near-infrared (NIR) laser irradiation, the as-prepared BSA-IrO2 NPs exhibited high photothermal conversion ability (54.3%) and good photostability. The in vitro drug release experiments displayed pH and NIR laser -triggered DOX release profiles, which could enhance the therapeutic anticancer effect. By utilizing this DOX loaded nanoplatform, effective synergistic chemo-photothermal therapy against human osteosarcoma can be realized, which has been systematically verified both in vitro and in vivo. Notably, in vivo pharmacokinetics studies showed that BSA-IrO2@DOX had prolonged blood circulation time due to the BSA component can improve the stealthiness of the nanoparticles during the blood circulation. Meanwhile, in vitro and in vivo toxicity studies demonstrated that the BSA-IrO2 NPs can act as biocompatible agents for drug delivery and cancer therapy. Therefore, this work presents a biomineralized iridium-based NPs with remarkable features and be used as a very potential therapeutic nanoplatform for cancer treatment.http://dx.doi.org/10.1080/10717544.2019.1662513iridium oxidebovine serum albuminphotothermalbiomineralizationsynergistic therapy |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Wenguang Gu Tao Zhang Junsheng Gao Yi Wang Dejian Li Ziwen Zhao Bo Jiang Zhiwei Dong Hui Liu |
spellingShingle |
Wenguang Gu Tao Zhang Junsheng Gao Yi Wang Dejian Li Ziwen Zhao Bo Jiang Zhiwei Dong Hui Liu Albumin-bioinspired iridium oxide nanoplatform with high photothermal conversion efficiency for synergistic chemo-photothermal of osteosarcoma Drug Delivery iridium oxide bovine serum albumin photothermal biomineralization synergistic therapy |
author_facet |
Wenguang Gu Tao Zhang Junsheng Gao Yi Wang Dejian Li Ziwen Zhao Bo Jiang Zhiwei Dong Hui Liu |
author_sort |
Wenguang Gu |
title |
Albumin-bioinspired iridium oxide nanoplatform with high photothermal conversion efficiency for synergistic chemo-photothermal of osteosarcoma |
title_short |
Albumin-bioinspired iridium oxide nanoplatform with high photothermal conversion efficiency for synergistic chemo-photothermal of osteosarcoma |
title_full |
Albumin-bioinspired iridium oxide nanoplatform with high photothermal conversion efficiency for synergistic chemo-photothermal of osteosarcoma |
title_fullStr |
Albumin-bioinspired iridium oxide nanoplatform with high photothermal conversion efficiency for synergistic chemo-photothermal of osteosarcoma |
title_full_unstemmed |
Albumin-bioinspired iridium oxide nanoplatform with high photothermal conversion efficiency for synergistic chemo-photothermal of osteosarcoma |
title_sort |
albumin-bioinspired iridium oxide nanoplatform with high photothermal conversion efficiency for synergistic chemo-photothermal of osteosarcoma |
publisher |
Taylor & Francis Group |
series |
Drug Delivery |
issn |
1071-7544 1521-0464 |
publishDate |
2019-01-01 |
description |
Protein-based nanocarriers with inherent biocompatibility have been widely served as building blocks to construct versatile therapeutic nanoplatforms. Herein, bovine serum albumin-iridium oxide nanoparticles (denoted BSA-IrO2 NPs) are successfully synthesized via one-step biomineralization approach. The BSA-IrO2 NPs exhibits uniform size (40 nm), superb biocompatibility and high drug loading capacity for doxorubicin (27.4 wt%). Under near-infrared (NIR) laser irradiation, the as-prepared BSA-IrO2 NPs exhibited high photothermal conversion ability (54.3%) and good photostability. The in vitro drug release experiments displayed pH and NIR laser -triggered DOX release profiles, which could enhance the therapeutic anticancer effect. By utilizing this DOX loaded nanoplatform, effective synergistic chemo-photothermal therapy against human osteosarcoma can be realized, which has been systematically verified both in vitro and in vivo. Notably, in vivo pharmacokinetics studies showed that BSA-IrO2@DOX had prolonged blood circulation time due to the BSA component can improve the stealthiness of the nanoparticles during the blood circulation. Meanwhile, in vitro and in vivo toxicity studies demonstrated that the BSA-IrO2 NPs can act as biocompatible agents for drug delivery and cancer therapy. Therefore, this work presents a biomineralized iridium-based NPs with remarkable features and be used as a very potential therapeutic nanoplatform for cancer treatment. |
topic |
iridium oxide bovine serum albumin photothermal biomineralization synergistic therapy |
url |
http://dx.doi.org/10.1080/10717544.2019.1662513 |
work_keys_str_mv |
AT wenguanggu albuminbioinspirediridiumoxidenanoplatformwithhighphotothermalconversionefficiencyforsynergisticchemophotothermalofosteosarcoma AT taozhang albuminbioinspirediridiumoxidenanoplatformwithhighphotothermalconversionefficiencyforsynergisticchemophotothermalofosteosarcoma AT junshenggao albuminbioinspirediridiumoxidenanoplatformwithhighphotothermalconversionefficiencyforsynergisticchemophotothermalofosteosarcoma AT yiwang albuminbioinspirediridiumoxidenanoplatformwithhighphotothermalconversionefficiencyforsynergisticchemophotothermalofosteosarcoma AT dejianli albuminbioinspirediridiumoxidenanoplatformwithhighphotothermalconversionefficiencyforsynergisticchemophotothermalofosteosarcoma AT ziwenzhao albuminbioinspirediridiumoxidenanoplatformwithhighphotothermalconversionefficiencyforsynergisticchemophotothermalofosteosarcoma AT bojiang albuminbioinspirediridiumoxidenanoplatformwithhighphotothermalconversionefficiencyforsynergisticchemophotothermalofosteosarcoma AT zhiweidong albuminbioinspirediridiumoxidenanoplatformwithhighphotothermalconversionefficiencyforsynergisticchemophotothermalofosteosarcoma AT huiliu albuminbioinspirediridiumoxidenanoplatformwithhighphotothermalconversionefficiencyforsynergisticchemophotothermalofosteosarcoma |
_version_ |
1725175028140474368 |