Cellular Uptake and Intracellular Phosphorylation of GS-441524: Implications for Its Effectiveness against COVID-19

Cellular Uptake and Intracellular Phosphorylation of GS-441524: Implications for Its Effectiveness against COVID-19

GS-441524 is an adenosine analog and the parent nucleoside of the prodrug remdesivir, which has received emergency approval for treatment of COVID-19. Recently, GS-441524 has been proposed to be effective in the treatment of COVID-19, perhaps even being superior to remdesivir for treatment of this d...

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Bibliographic Details
Main Authors: Henrik Berg Rasmussen, Gesche Jürgens, Ragnar Thomsen, Olivier Taboureau, Kornelius Zeth, Poul Erik Hansen, Peter Riis Hansen
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Viruses
Subjects:
GS-441524
adenosine analogs
COVID-19
adenosine transporters
adenosine kinase
adenosine levels
Online Access:https://www.mdpi.com/1999-4915/13/7/1369

Internet

https://www.mdpi.com/1999-4915/13/7/1369

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