Dysregulated expression of death, stress and mitochondrion related genes in the sciatic nerve of presymptomatic SOD1G93A mouse model of Amyotrophic Lateral Sclerosis

Dysregulated expression of death, stress and mitochondrion related genes in the sciatic nerve of presymptomatic SOD1G93A mouse model of Amyotrophic Lateral Sclerosis

Schwann cells are the main source of paracrine support to motor neurons. Oxidative stress and mitochondrial dysfunction have been correlated to motor neuron death in Amyotrophic Lateral Sclerosis (ALS). Despite the involvement of Schwann cells in early neuromuscular disruption in ALS, detailed molec...

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Bibliographic Details
Main Authors: Chrystian Junqueira Alves, Jessica Ruivo Maximino, Gerson eChadi
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-09-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Schwann Cells
Sciatic Nerve
Microarray
ALS
SOD1G93A
pre-symptomatic
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00332/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00332/full

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