High frequency stimulation of the anterior vermis modulates behavioural response to chronic stress: involvement of the prefrontal cortex and dorsal raphe?
Some evidence suggests that the cerebellum modulates affect via connectivities with mood-regulating corticolimbic structures, such as the prefrontal cortex and monoamine nuclei. In rats exposed to chronic unpredictable stress (CUS), we examined the neuro-behavioural effects of high frequency stimula...
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doaj-15e32e62c96e45b09f04102c1b06523d2021-03-22T12:46:24ZengElsevierNeurobiology of Disease1095-953X2018-08-01116166178High frequency stimulation of the anterior vermis modulates behavioural response to chronic stress: involvement of the prefrontal cortex and dorsal raphe?Francis Rodriguez Bambico0Stefano Comai1Mustansir Diwan2S.M. Nageeb Hasan3Joshua Dean Conway4Soroush Darvish-Ghane5Clement Hamani6Gabriella Gobbi7José N. Nobrega8Department of Psychology, Memorial University of Newfoundland, NL A1B 3X9, Canada; Behavioural Neurobiology Laboratory, Campbell Family Mental Health Research Institute and Research Imaging Center, Center for Addiction and Mental Health, Toronto, Ontario M5T 1R82, Canada; Corresponding author at: Department of Psychology, Memorial University of Newfoundland, NL A1B 3X93, Canada.Neurobiological Psychiatry Unit, Department of Psychiatry, Irving Ludmer Research and Training Building, McGill University, Quebec H3A 1A1, CanadaBehavioural Neurobiology Laboratory, Campbell Family Mental Health Research Institute and Research Imaging Center, Center for Addiction and Mental Health, Toronto, Ontario M5T 1R82, CanadaDepartment of Psychology, Memorial University of Newfoundland, NL A1B 3X9, CanadaDepartment of Psychology, Memorial University of Newfoundland, NL A1B 3X9, CanadaBehavioural Neurobiology Laboratory, Campbell Family Mental Health Research Institute and Research Imaging Center, Center for Addiction and Mental Health, Toronto, Ontario M5T 1R82, CanadaBehavioural Neurobiology Laboratory, Campbell Family Mental Health Research Institute and Research Imaging Center, Center for Addiction and Mental Health, Toronto, Ontario M5T 1R82, CanadaNeurobiological Psychiatry Unit, Department of Psychiatry, Irving Ludmer Research and Training Building, McGill University, Quebec H3A 1A1, CanadaBehavioural Neurobiology Laboratory, Campbell Family Mental Health Research Institute and Research Imaging Center, Center for Addiction and Mental Health, Toronto, Ontario M5T 1R82, CanadaSome evidence suggests that the cerebellum modulates affect via connectivities with mood-regulating corticolimbic structures, such as the prefrontal cortex and monoamine nuclei. In rats exposed to chronic unpredictable stress (CUS), we examined the neuro-behavioural effects of high frequency stimulation and surgical ablation/disconnection of the cerebellar vermis. CUS reduced sucrose preference, increased novelty-induced feeding suppression and passive coping. These depressive-like behaviours were associated with decreased cerebellar zif268 expression, indicating possible cerebellar involvement in stress pathology. These were paralleled by decreased vermal Purkinje simple and complex spiking activity and raphe serotonergic activity. Protracted (24-h) vermal stimulation reversed these behavioural deficits through serotonin-mediated mechanisms since this effect was abrogated by the serotonin-depleting agent pCPA. Vermal stimulation and disconnection lesion also enhanced serotonergic activity, but did not modify prefrontocortical pyramidal firing. This effect was likely mediated by 5-HT1A receptors (5-HT1AR). Indeed, acute vermal stimulation mimicked the effect of the 5-HT1AR agonist 8-OH-DPAT in inhibiting serotonergic activity, which was prevented by pre-treatment with the 5-HT1AR antagonist WAY100,635. These results demonstrate vermal involvement in depressive-type behaviour via its modulatory action on serotonergic neurons. They further suggest that vermal and mPFC stimulation may bestow therapeutic benefits via parallel pathways.http://www.sciencedirect.com/science/article/pii/S0969996118300871AnhedoniaAntidepressantCerebellar vermisDeep brain stimulationDorsal rapheElectrophysiology |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Francis Rodriguez Bambico Stefano Comai Mustansir Diwan S.M. Nageeb Hasan Joshua Dean Conway Soroush Darvish-Ghane Clement Hamani Gabriella Gobbi José N. Nobrega |
spellingShingle |
Francis Rodriguez Bambico Stefano Comai Mustansir Diwan S.M. Nageeb Hasan Joshua Dean Conway Soroush Darvish-Ghane Clement Hamani Gabriella Gobbi José N. Nobrega High frequency stimulation of the anterior vermis modulates behavioural response to chronic stress: involvement of the prefrontal cortex and dorsal raphe? Neurobiology of Disease Anhedonia Antidepressant Cerebellar vermis Deep brain stimulation Dorsal raphe Electrophysiology |
author_facet |
Francis Rodriguez Bambico Stefano Comai Mustansir Diwan S.M. Nageeb Hasan Joshua Dean Conway Soroush Darvish-Ghane Clement Hamani Gabriella Gobbi José N. Nobrega |
author_sort |
Francis Rodriguez Bambico |
title |
High frequency stimulation of the anterior vermis modulates behavioural response to chronic stress: involvement of the prefrontal cortex and dorsal raphe? |
title_short |
High frequency stimulation of the anterior vermis modulates behavioural response to chronic stress: involvement of the prefrontal cortex and dorsal raphe? |
title_full |
High frequency stimulation of the anterior vermis modulates behavioural response to chronic stress: involvement of the prefrontal cortex and dorsal raphe? |
title_fullStr |
High frequency stimulation of the anterior vermis modulates behavioural response to chronic stress: involvement of the prefrontal cortex and dorsal raphe? |
title_full_unstemmed |
High frequency stimulation of the anterior vermis modulates behavioural response to chronic stress: involvement of the prefrontal cortex and dorsal raphe? |
title_sort |
high frequency stimulation of the anterior vermis modulates behavioural response to chronic stress: involvement of the prefrontal cortex and dorsal raphe? |
publisher |
Elsevier |
series |
Neurobiology of Disease |
issn |
1095-953X |
publishDate |
2018-08-01 |
description |
Some evidence suggests that the cerebellum modulates affect via connectivities with mood-regulating corticolimbic structures, such as the prefrontal cortex and monoamine nuclei. In rats exposed to chronic unpredictable stress (CUS), we examined the neuro-behavioural effects of high frequency stimulation and surgical ablation/disconnection of the cerebellar vermis. CUS reduced sucrose preference, increased novelty-induced feeding suppression and passive coping. These depressive-like behaviours were associated with decreased cerebellar zif268 expression, indicating possible cerebellar involvement in stress pathology. These were paralleled by decreased vermal Purkinje simple and complex spiking activity and raphe serotonergic activity. Protracted (24-h) vermal stimulation reversed these behavioural deficits through serotonin-mediated mechanisms since this effect was abrogated by the serotonin-depleting agent pCPA. Vermal stimulation and disconnection lesion also enhanced serotonergic activity, but did not modify prefrontocortical pyramidal firing. This effect was likely mediated by 5-HT1A receptors (5-HT1AR). Indeed, acute vermal stimulation mimicked the effect of the 5-HT1AR agonist 8-OH-DPAT in inhibiting serotonergic activity, which was prevented by pre-treatment with the 5-HT1AR antagonist WAY100,635. These results demonstrate vermal involvement in depressive-type behaviour via its modulatory action on serotonergic neurons. They further suggest that vermal and mPFC stimulation may bestow therapeutic benefits via parallel pathways. |
topic |
Anhedonia Antidepressant Cerebellar vermis Deep brain stimulation Dorsal raphe Electrophysiology |
url |
http://www.sciencedirect.com/science/article/pii/S0969996118300871 |
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