A Review of Mathematics Determining Solute Uptake at the Blood–Brain Barrier in Normal and Pathological Conditions

A Review of Mathematics Determining Solute Uptake at the Blood–Brain Barrier in Normal and Pathological Conditions

The blood–brain barrier (BBB) limits movement of solutes from the lumen of the brain microvascular capillary system into the parenchyma. The unidirectional transfer constant, <i>K<sub>in</sub></i>, is the rate at which transport across the BBB occurs for individual molecules....

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Bibliographic Details
Main Authors: Samuel A. Sprowls, Pushkar Saralkar, Tasneem Arsiwala, Christopher E. Adkins, Kathryn E. Blethen, Vincenzo J. Pizzuti, Neal Shah, Ross Fladeland, Paul R. Lockman
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Pharmaceutics
Subjects:
pharmacokinetics
blood–brain barrier
brain
magnetic-resonance imaging
preclinical models
Online Access:https://www.mdpi.com/1999-4923/13/5/756

Internet

https://www.mdpi.com/1999-4923/13/5/756

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