Blunting of cardioprotective actions of estrogen in female rodent heart linked to altered expression of cardiac tissue chymase and ACE2

Blunting of cardioprotective actions of estrogen in female rodent heart linked to altered expression of cardiac tissue chymase and ACE2

Background: Diastolic dysfunction develops in response to hypertension and estrogen (E2) loss and is a forerunner to heart failure (HF) in women. The cardiac renin–angiotensin system (RAS) contributes to diastolic dysfunction, but its role with respect to E2 and blood pressure remain unclear. Method...

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Bibliographic Details
Main Authors: Jaqueline S. da Silva, Daniele Gabriel-Costa, Hao Wang, Sarfaraz Ahmad, Xuming Sun, Jasmina Varagic, Roberto T Sudo, Carlos M Ferrario, Louis J Dell Italia, Gisele Zapata-Sudo, Leanne Groban
Format: Article
Language:English
Published: Hindawi - SAGE Publishing 2017-07-01
Series:Journal of the Renin-Angiotensin-Aldosterone System
Online Access:https://doi.org/10.1177/1470320317722270

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