Protection against Shiga Toxins

Protection against Shiga Toxins

Shiga toxins consist of an A-moiety and five B-moieties able to bind the neutral glycosphingolipid globotriaosylceramide (Gb3) on the cell surface. To intoxicate cells efficiently, the toxin A-moiety has to be cleaved by furin and transported retrogradely to the Golgi apparatus and to the endoplasmi...

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Bibliographic Details
Main Authors:	Simona Kavaliauskiene, Anne Berit Dyve Lingelem, Tore Skotland, Kirsten Sandvig
Format:	Article
Language:	English
Published:	MDPI AG 2017-02-01
Series:	Toxins
Subjects:	Shiga toxin Stx1 Stx2 hemolytic uremic syndrome inhibitors chloroquine fluorodeoxyglucose Mn2+
Online Access:	http://www.mdpi.com/2072-6651/9/2/44

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