Serum levels of melatonin and cytokines in multiple sclerosis
Cytokines are important factors of the immune system in autoimmune diseases such as multiple sclerosis (MS) in which damage caused by oxidants plays a major role in the pathology. Melatonin secreted by the pineal gland has recently been considered as an antioxidant. The purpose of this study was to...
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doaj-160401a130184f63833da3045cb9f1c32021-02-02T05:28:04ZengElsevierBiomedical Journal2319-41702320-28902014-04-01372909210.4103/2319-4170.125885Serum levels of melatonin and cytokines in multiple sclerosisNaser Farhadi0Shahrbanoo Oryan1Mohammad Nabiuni2Cellular and Molecular Research Center, Yasuj University of Medical Sciences, Yasuj, IranDepartment of Biology, Kharazmi University, Tehran, IranDepartment of Biology, Kharazmi University, Tehran, IranCytokines are important factors of the immune system in autoimmune diseases such as multiple sclerosis (MS) in which damage caused by oxidants plays a major role in the pathology. Melatonin secreted by the pineal gland has recently been considered as an antioxidant. The purpose of this study was to determine the relationship between melatonin and cytokines in patients with MS. Thirty patients with MS and 30 healthy controls were selected. Serum levels of melatonin and cytokines, including interleukin-4, interferon-γ, and tumor necrosis factor alpha (TNF-α), were detected in all participants by the enzyme-linked immunosorbent assay (ELISA) method. There was a significant difference between patient and control groups in the levels of melatonin and TNF-α. Also, no significant correlation between the serum levels of melatonin and cytokines in both patient and control groups was seen. We concluded that decrease of melatonin and subsequent increase of pro-inflammatory cytokine, TNF-α, could be a factor in the inflammatory reactions in the pathologic process of MS.http://www.biomedj.org/article.asp?issn=2319-4170;year=2014;volume=37;issue=2;spage=90;epage=92;aulast=Farhadicytokinesimmune systemmelatoninmultiple sclerosispineal gland |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Naser Farhadi Shahrbanoo Oryan Mohammad Nabiuni |
spellingShingle |
Naser Farhadi Shahrbanoo Oryan Mohammad Nabiuni Serum levels of melatonin and cytokines in multiple sclerosis Biomedical Journal cytokines immune system melatonin multiple sclerosis pineal gland |
author_facet |
Naser Farhadi Shahrbanoo Oryan Mohammad Nabiuni |
author_sort |
Naser Farhadi |
title |
Serum levels of melatonin and cytokines in multiple sclerosis |
title_short |
Serum levels of melatonin and cytokines in multiple sclerosis |
title_full |
Serum levels of melatonin and cytokines in multiple sclerosis |
title_fullStr |
Serum levels of melatonin and cytokines in multiple sclerosis |
title_full_unstemmed |
Serum levels of melatonin and cytokines in multiple sclerosis |
title_sort |
serum levels of melatonin and cytokines in multiple sclerosis |
publisher |
Elsevier |
series |
Biomedical Journal |
issn |
2319-4170 2320-2890 |
publishDate |
2014-04-01 |
description |
Cytokines are important factors of the immune system in autoimmune diseases such as multiple sclerosis (MS) in which damage caused by oxidants plays a major role in the pathology. Melatonin secreted by the pineal gland has recently been considered as an antioxidant. The purpose of this study was to determine the relationship between melatonin and cytokines in patients with MS. Thirty patients with MS and 30 healthy controls were selected. Serum levels of melatonin and cytokines, including interleukin-4, interferon-γ, and tumor necrosis factor alpha (TNF-α), were detected in all participants by the enzyme-linked immunosorbent assay (ELISA) method. There was a significant difference between patient and control groups in the levels of melatonin and TNF-α. Also, no significant correlation between the serum levels of melatonin and cytokines in both patient and control groups was seen. We concluded that decrease of melatonin and subsequent increase of pro-inflammatory cytokine, TNF-α, could be a factor in the inflammatory reactions in the pathologic process of MS. |
topic |
cytokines immune system melatonin multiple sclerosis pineal gland |
url |
http://www.biomedj.org/article.asp?issn=2319-4170;year=2014;volume=37;issue=2;spage=90;epage=92;aulast=Farhadi |
work_keys_str_mv |
AT naserfarhadi serumlevelsofmelatoninandcytokinesinmultiplesclerosis AT shahrbanoooryan serumlevelsofmelatoninandcytokinesinmultiplesclerosis AT mohammadnabiuni serumlevelsofmelatoninandcytokinesinmultiplesclerosis |
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