Long-Term Fipronil Treatment Induces Hyperactivity in Female Mice
Fipronil is an insecticide widely used for veterinary and agricultural purposes. While its insecticidal properties mostly rely on its high affinity antagonistic activity on insect γ aminobutyric acid (GABA) receptors, fipronil and its main metabolite fipronil sulfone nevertheless display no...
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doaj-161438abf33343c4bb250a6e7e091fd12020-11-25T02:15:07ZengMDPI AGInternational Journal of Environmental Research and Public Health1660-46012020-02-01175157910.3390/ijerph17051579ijerph17051579Long-Term Fipronil Treatment Induces Hyperactivity in Female MiceSvenja Koslowski0Camille Latapy1Pierrïck Auvray2Marc Blondel3Laurent Meijer4Perha Pharmaceuticals & ManRos Therapeutics, Centre de Perharidy, 29680 Roscoff, Bretagne, FranceC.RIS Pharma, Parc Technopolitain, Atalante Saint Malo, 35400 Saint Malo, FranceC.RIS Pharma, Parc Technopolitain, Atalante Saint Malo, 35400 Saint Malo, FranceUniversité Brest, Inserm, EFS, UMR1078, GGB, F-29200 Brest, FrancePerha Pharmaceuticals & ManRos Therapeutics, Centre de Perharidy, 29680 Roscoff, Bretagne, FranceFipronil is an insecticide widely used for veterinary and agricultural purposes. While its insecticidal properties mostly rely on its high affinity antagonistic activity on insect γ aminobutyric acid (GABA) receptors, fipronil and its main metabolite fipronil sulfone nevertheless display non-negligible affinity for mammalian GABA<sub>A</sub> receptor. As several environmental toxicants have been shown to raise the risk of developing various neurodegenerative disorders, the aim of this study was to evaluate whether long-term low dose administration of fipronil could lead to cognitive deficiencies. Our results indicate that long-term fipronil treatment leads to behavioral perturbations in mice, indicating an accumulative effect of sustained exposure to low dose of fipronil. Although no memory impairment was observed during the course of our study, we noticed a significant hyperlocomotion behavior after 43 weeks of weekly fipronil administration, which is consistent with its direct effect on the GABAergic system.https://www.mdpi.com/1660-4601/17/5/1579fipronilhyperlocomotionmemory impairmentdementiainsecticide |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Svenja Koslowski Camille Latapy Pierrïck Auvray Marc Blondel Laurent Meijer |
spellingShingle |
Svenja Koslowski Camille Latapy Pierrïck Auvray Marc Blondel Laurent Meijer Long-Term Fipronil Treatment Induces Hyperactivity in Female Mice International Journal of Environmental Research and Public Health fipronil hyperlocomotion memory impairment dementia insecticide |
author_facet |
Svenja Koslowski Camille Latapy Pierrïck Auvray Marc Blondel Laurent Meijer |
author_sort |
Svenja Koslowski |
title |
Long-Term Fipronil Treatment Induces Hyperactivity in Female Mice |
title_short |
Long-Term Fipronil Treatment Induces Hyperactivity in Female Mice |
title_full |
Long-Term Fipronil Treatment Induces Hyperactivity in Female Mice |
title_fullStr |
Long-Term Fipronil Treatment Induces Hyperactivity in Female Mice |
title_full_unstemmed |
Long-Term Fipronil Treatment Induces Hyperactivity in Female Mice |
title_sort |
long-term fipronil treatment induces hyperactivity in female mice |
publisher |
MDPI AG |
series |
International Journal of Environmental Research and Public Health |
issn |
1660-4601 |
publishDate |
2020-02-01 |
description |
Fipronil is an insecticide widely used for veterinary and agricultural purposes. While its insecticidal properties mostly rely on its high affinity antagonistic activity on insect γ aminobutyric acid (GABA) receptors, fipronil and its main metabolite fipronil sulfone nevertheless display non-negligible affinity for mammalian GABA<sub>A</sub> receptor. As several environmental toxicants have been shown to raise the risk of developing various neurodegenerative disorders, the aim of this study was to evaluate whether long-term low dose administration of fipronil could lead to cognitive deficiencies. Our results indicate that long-term fipronil treatment leads to behavioral perturbations in mice, indicating an accumulative effect of sustained exposure to low dose of fipronil. Although no memory impairment was observed during the course of our study, we noticed a significant hyperlocomotion behavior after 43 weeks of weekly fipronil administration, which is consistent with its direct effect on the GABAergic system. |
topic |
fipronil hyperlocomotion memory impairment dementia insecticide |
url |
https://www.mdpi.com/1660-4601/17/5/1579 |
work_keys_str_mv |
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