Conserved collateral antibiotic susceptibility networks in diverse clinical strains of Escherichia coli

Resistance to one antibiotic can in some cases increase susceptibility to other antibiotics. Here, Podnecky et al. study these collateral responses in E. coli clinical isolates and show that efflux-related resistance mechanisms and relative fitness of the strains are principal contributors to this p...

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Main Authors:	Nicole L. Podnecky, Elizabeth G. A. Fredheim, Julia Kloos, Vidar Sørum, Raul Primicerio, Adam P. Roberts, Daniel E. Rozen, Ørjan Samuelsen, Pål J. Johnsen
Format:	Article
Language:	English
Published:	Nature Publishing Group 2018-09-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-018-06143-y

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spelling	doaj-161a82352aa642d2845c098a4e132f542021-05-11T10:28:37ZengNature Publishing GroupNature Communications2041-17232018-09-019111110.1038/s41467-018-06143-yConserved collateral antibiotic susceptibility networks in diverse clinical strains of Escherichia coliNicole L. Podnecky0Elizabeth G. A. Fredheim1Julia Kloos2Vidar Sørum3Raul Primicerio4Adam P. Roberts5Daniel E. Rozen6Ørjan Samuelsen7Pål J. Johnsen8Department of Pharmacy, Faculty of Health Sciences, UiT The Arctic University of NorwayDepartment of Pharmacy, Faculty of Health Sciences, UiT The Arctic University of NorwayDepartment of Pharmacy, Faculty of Health Sciences, UiT The Arctic University of NorwayDepartment of Pharmacy, Faculty of Health Sciences, UiT The Arctic University of NorwayDepartment of Pharmacy, Faculty of Health Sciences, UiT The Arctic University of NorwayDepartment of Parasitology, Liverpool School of Tropical MedicineInstitute of Biology, Leiden UniversityDepartment of Pharmacy, Faculty of Health Sciences, UiT The Arctic University of NorwayDepartment of Pharmacy, Faculty of Health Sciences, UiT The Arctic University of NorwayResistance to one antibiotic can in some cases increase susceptibility to other antibiotics. Here, Podnecky et al. study these collateral responses in E. coli clinical isolates and show that efflux-related resistance mechanisms and relative fitness of the strains are principal contributors to this phenomenon.https://doi.org/10.1038/s41467-018-06143-y
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Nicole L. Podnecky Elizabeth G. A. Fredheim Julia Kloos Vidar Sørum Raul Primicerio Adam P. Roberts Daniel E. Rozen Ørjan Samuelsen Pål J. Johnsen
spellingShingle	Nicole L. Podnecky Elizabeth G. A. Fredheim Julia Kloos Vidar Sørum Raul Primicerio Adam P. Roberts Daniel E. Rozen Ørjan Samuelsen Pål J. Johnsen Conserved collateral antibiotic susceptibility networks in diverse clinical strains of Escherichia coli Nature Communications
author_facet	Nicole L. Podnecky Elizabeth G. A. Fredheim Julia Kloos Vidar Sørum Raul Primicerio Adam P. Roberts Daniel E. Rozen Ørjan Samuelsen Pål J. Johnsen
author_sort	Nicole L. Podnecky
title	Conserved collateral antibiotic susceptibility networks in diverse clinical strains of Escherichia coli
title_short	Conserved collateral antibiotic susceptibility networks in diverse clinical strains of Escherichia coli
title_full	Conserved collateral antibiotic susceptibility networks in diverse clinical strains of Escherichia coli
title_fullStr	Conserved collateral antibiotic susceptibility networks in diverse clinical strains of Escherichia coli
title_full_unstemmed	Conserved collateral antibiotic susceptibility networks in diverse clinical strains of Escherichia coli
title_sort	conserved collateral antibiotic susceptibility networks in diverse clinical strains of escherichia coli
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2018-09-01
description	Resistance to one antibiotic can in some cases increase susceptibility to other antibiotics. Here, Podnecky et al. study these collateral responses in E. coli clinical isolates and show that efflux-related resistance mechanisms and relative fitness of the strains are principal contributors to this phenomenon.
url	https://doi.org/10.1038/s41467-018-06143-y
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Conserved collateral antibiotic susceptibility networks in diverse clinical strains of Escherichia coli

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