Targeting C-myc G-Quadruplex: Dual Recognition by Aminosugar-Bisbenzimidazoles with Varying Linker Lengths
G-quadruplexes are therapeutically important biological targets. In this report, we present biophysical studies of neomycin-Hoechst 33258 conjugates binding to a G-quadruplex derived from the C-myc promoter sequence. Our studies indicate that conjugation of neomycin to a G-quadruplex binder, Hoechs...
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Online Access: | http://www.mdpi.com/1420-3049/18/11/14228 |
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doaj-161e4ab1151347f9b10bb95646a6707a2020-11-24T23:01:07ZengMDPI AGMolecules1420-30492013-11-011811142281424010.3390/molecules181114228molecules181114228Targeting C-myc G-Quadruplex: Dual Recognition by Aminosugar-Bisbenzimidazoles with Varying Linker LengthsNihar Ranjan0Dev P. Arya1Laboratory of Medicinal Chemistry, Department of Chemistry, Clemson University, Clemson, SC 29634, USALaboratory of Medicinal Chemistry, Department of Chemistry, Clemson University, Clemson, SC 29634, USAG-quadruplexes are therapeutically important biological targets. In this report, we present biophysical studies of neomycin-Hoechst 33258 conjugates binding to a G-quadruplex derived from the C-myc promoter sequence. Our studies indicate that conjugation of neomycin to a G-quadruplex binder, Hoechst 33258, enhances its binding. The enhancement in G-quadruplex binding of these conjugates varies with the length and composition of the linkers joining the neomycin and Hoechst 33258 units.http://www.mdpi.com/1420-3049/18/11/14228G-quadruplexneomycinHoechst 33258oncogenesFIDC-myc |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Nihar Ranjan Dev P. Arya |
spellingShingle |
Nihar Ranjan Dev P. Arya Targeting C-myc G-Quadruplex: Dual Recognition by Aminosugar-Bisbenzimidazoles with Varying Linker Lengths Molecules G-quadruplex neomycin Hoechst 33258 oncogenes FID C-myc |
author_facet |
Nihar Ranjan Dev P. Arya |
author_sort |
Nihar Ranjan |
title |
Targeting C-myc G-Quadruplex: Dual Recognition by Aminosugar-Bisbenzimidazoles with Varying Linker Lengths |
title_short |
Targeting C-myc G-Quadruplex: Dual Recognition by Aminosugar-Bisbenzimidazoles with Varying Linker Lengths |
title_full |
Targeting C-myc G-Quadruplex: Dual Recognition by Aminosugar-Bisbenzimidazoles with Varying Linker Lengths |
title_fullStr |
Targeting C-myc G-Quadruplex: Dual Recognition by Aminosugar-Bisbenzimidazoles with Varying Linker Lengths |
title_full_unstemmed |
Targeting C-myc G-Quadruplex: Dual Recognition by Aminosugar-Bisbenzimidazoles with Varying Linker Lengths |
title_sort |
targeting c-myc g-quadruplex: dual recognition by aminosugar-bisbenzimidazoles with varying linker lengths |
publisher |
MDPI AG |
series |
Molecules |
issn |
1420-3049 |
publishDate |
2013-11-01 |
description |
G-quadruplexes are therapeutically important biological targets. In this report, we present biophysical studies of neomycin-Hoechst 33258 conjugates binding to a G-quadruplex derived from the C-myc promoter sequence. Our studies indicate that conjugation of neomycin to a G-quadruplex binder, Hoechst 33258, enhances its binding. The enhancement in G-quadruplex binding of these conjugates varies with the length and composition of the linkers joining the neomycin and Hoechst 33258 units. |
topic |
G-quadruplex neomycin Hoechst 33258 oncogenes FID C-myc |
url |
http://www.mdpi.com/1420-3049/18/11/14228 |
work_keys_str_mv |
AT niharranjan targetingcmycgquadruplexdualrecognitionbyaminosugarbisbenzimidazoleswithvaryinglinkerlengths AT devparya targetingcmycgquadruplexdualrecognitionbyaminosugarbisbenzimidazoleswithvaryinglinkerlengths |
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