Targeting C-myc G-Quadruplex: Dual Recognition by Aminosugar-Bisbenzimidazoles with Varying Linker Lengths

G-quadruplexes are therapeutically important biological targets. In this report, we present biophysical studies of neomycin-Hoechst 33258 conjugates binding to a G-quadruplex derived from the C-myc promoter sequence. Our studies indicate that conjugation of neomycin to a G-quadruplex binder, Hoechs...

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Main Authors:	Nihar Ranjan, Dev P. Arya
Format:	Article
Language:	English
Published:	MDPI AG 2013-11-01
Series:	Molecules
Subjects:	G-quadruplex neomycin Hoechst 33258 oncogenes FID C-myc
Online Access:	http://www.mdpi.com/1420-3049/18/11/14228

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spelling	doaj-161e4ab1151347f9b10bb95646a6707a2020-11-24T23:01:07ZengMDPI AGMolecules1420-30492013-11-011811142281424010.3390/molecules181114228molecules181114228Targeting C-myc G-Quadruplex: Dual Recognition by Aminosugar-Bisbenzimidazoles with Varying Linker LengthsNihar Ranjan0Dev P. Arya1Laboratory of Medicinal Chemistry, Department of Chemistry, Clemson University, Clemson, SC 29634, USALaboratory of Medicinal Chemistry, Department of Chemistry, Clemson University, Clemson, SC 29634, USAG-quadruplexes are therapeutically important biological targets. In this report, we present biophysical studies of neomycin-Hoechst 33258 conjugates binding to a G-quadruplex derived from the C-myc promoter sequence. Our studies indicate that conjugation of neomycin to a G-quadruplex binder, Hoechst 33258, enhances its binding. The enhancement in G-quadruplex binding of these conjugates varies with the length and composition of the linkers joining the neomycin and Hoechst 33258 units.http://www.mdpi.com/1420-3049/18/11/14228G-quadruplexneomycinHoechst 33258oncogenesFIDC-myc
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Nihar Ranjan Dev P. Arya
spellingShingle	Nihar Ranjan Dev P. Arya Targeting C-myc G-Quadruplex: Dual Recognition by Aminosugar-Bisbenzimidazoles with Varying Linker Lengths Molecules G-quadruplex neomycin Hoechst 33258 oncogenes FID C-myc
author_facet	Nihar Ranjan Dev P. Arya
author_sort	Nihar Ranjan
title	Targeting C-myc G-Quadruplex: Dual Recognition by Aminosugar-Bisbenzimidazoles with Varying Linker Lengths
title_short	Targeting C-myc G-Quadruplex: Dual Recognition by Aminosugar-Bisbenzimidazoles with Varying Linker Lengths
title_full	Targeting C-myc G-Quadruplex: Dual Recognition by Aminosugar-Bisbenzimidazoles with Varying Linker Lengths
title_fullStr	Targeting C-myc G-Quadruplex: Dual Recognition by Aminosugar-Bisbenzimidazoles with Varying Linker Lengths
title_full_unstemmed	Targeting C-myc G-Quadruplex: Dual Recognition by Aminosugar-Bisbenzimidazoles with Varying Linker Lengths
title_sort	targeting c-myc g-quadruplex: dual recognition by aminosugar-bisbenzimidazoles with varying linker lengths
publisher	MDPI AG
series	Molecules
issn	1420-3049
publishDate	2013-11-01
description	G-quadruplexes are therapeutically important biological targets. In this report, we present biophysical studies of neomycin-Hoechst 33258 conjugates binding to a G-quadruplex derived from the C-myc promoter sequence. Our studies indicate that conjugation of neomycin to a G-quadruplex binder, Hoechst 33258, enhances its binding. The enhancement in G-quadruplex binding of these conjugates varies with the length and composition of the linkers joining the neomycin and Hoechst 33258 units.
topic	G-quadruplex neomycin Hoechst 33258 oncogenes FID C-myc
url	http://www.mdpi.com/1420-3049/18/11/14228
work_keys_str_mv	AT niharranjan targetingcmycgquadruplexdualrecognitionbyaminosugarbisbenzimidazoleswithvaryinglinkerlengths AT devparya targetingcmycgquadruplexdualrecognitionbyaminosugarbisbenzimidazoleswithvaryinglinkerlengths
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Targeting C-myc G-Quadruplex: Dual Recognition by Aminosugar-Bisbenzimidazoles with Varying Linker Lengths

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