Pathological Femoral Fracture due to Osteoporosis and Hypophosphatemic Osteomalacia Following Adefovir Therapy in a Patient with Chronic Hepatitis B

Pathological Femoral Fracture due to Osteoporosis and Hypophosphatemic Osteomalacia Following Adefovir Therapy in a Patient with Chronic Hepatitis B

Adefovir dipivoxil (ADV) is a nucleotide analogue used in the chronic hepatitis B treatment. Proximal renal tubular dysfunction is one of the adverse effects of this agent and characterized with hypophosphatemia and osteomalacia. However, reduced bone mineral density with fracture due to ADV therapy...

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Bibliographic Details
Main Authors: Sevilay Batıbay, Duygu Geler Külcü, Nilgün Mesci, Borçak Çağlar Ruhi, Zerrin Şahin, Hasan Gündoğdu
Format: Article
Language:English
Published: Galenos Yayinevi 2018-08-01
Series:Türk Osteoporoz Dergisi
Subjects:
Adefovir dipivoxil
hypophosphatemia
osteomalacia
osteoporosis
fracture
Online Access:http://cms.galenos.com.tr/Uploads/Article_19913/TOD-24-59-En.pdf
Description
Summary:Adefovir dipivoxil (ADV) is a nucleotide analogue used in the chronic hepatitis B treatment. Proximal renal tubular dysfunction is one of the adverse effects of this agent and characterized with hypophosphatemia and osteomalacia. However, reduced bone mineral density with fracture due to ADV therapy has not been reported before. We aimed to report a 55-year-old male patient with proximal femur fracture who developed hypophosphatemic osteomalacia while using low dose of adefovir (10 mg/day) for chronic hepatitis B treatment for 10 years.
ISSN:2147-2653

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