Blue light regenerates functional visual pigments in mammals through a retinyl-phospholipid intermediate

Blue light regenerates functional visual pigments in mammals through a retinyl-phospholipid intermediate

It is currently thought that visual pigments in vertebrate photoreceptors are regenerated exclusively through enzymatic cycles. Here the authors show that mammalian photoreceptors also regenerate opsin pigments in light through photoisomerization of N-ret-PE (N-retinylidene-phosphatidylethanolamine.

Bibliographic Details
Main Authors: Joanna J. Kaylor, Tongzhou Xu, Norianne T. Ingram, Avian Tsan, Hayk Hakobyan, Gordon L. Fain, Gabriel H. Travis
Format: Article
Language:English
Published: Nature Publishing Group 2017-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-00018-4
id doaj-1627c4ab61794e10891586d484023cf9
record_format Article
spelling doaj-1627c4ab61794e10891586d484023cf92021-01-31T12:25:10ZengNature Publishing GroupNature Communications2041-17232017-05-018111010.1038/s41467-017-00018-4Blue light regenerates functional visual pigments in mammals through a retinyl-phospholipid intermediateJoanna J. Kaylor0Tongzhou Xu1Norianne T. Ingram2Avian Tsan3Hayk Hakobyan4Gordon L. Fain5Gabriel H. Travis6Jules Stein Eye Institute, University of California Los Angeles School of MedicineJules Stein Eye Institute, University of California Los Angeles School of MedicineJules Stein Eye Institute, University of California Los Angeles School of MedicineJules Stein Eye Institute, University of California Los Angeles School of MedicineJules Stein Eye Institute, University of California Los Angeles School of MedicineJules Stein Eye Institute, University of California Los Angeles School of MedicineJules Stein Eye Institute, University of California Los Angeles School of MedicineIt is currently thought that visual pigments in vertebrate photoreceptors are regenerated exclusively through enzymatic cycles. Here the authors show that mammalian photoreceptors also regenerate opsin pigments in light through photoisomerization of N-ret-PE (N-retinylidene-phosphatidylethanolamine.https://doi.org/10.1038/s41467-017-00018-4
collection DOAJ
language English
format Article
sources DOAJ
author Joanna J. Kaylor
Tongzhou Xu
Norianne T. Ingram
Avian Tsan
Hayk Hakobyan
Gordon L. Fain
Gabriel H. Travis
spellingShingle Joanna J. Kaylor
Tongzhou Xu
Norianne T. Ingram
Avian Tsan
Hayk Hakobyan
Gordon L. Fain
Gabriel H. Travis
Blue light regenerates functional visual pigments in mammals through a retinyl-phospholipid intermediate
Nature Communications
author_facet Joanna J. Kaylor
Tongzhou Xu
Norianne T. Ingram
Avian Tsan
Hayk Hakobyan
Gordon L. Fain
Gabriel H. Travis
author_sort Joanna J. Kaylor
title Blue light regenerates functional visual pigments in mammals through a retinyl-phospholipid intermediate
title_short Blue light regenerates functional visual pigments in mammals through a retinyl-phospholipid intermediate
title_full Blue light regenerates functional visual pigments in mammals through a retinyl-phospholipid intermediate
title_fullStr Blue light regenerates functional visual pigments in mammals through a retinyl-phospholipid intermediate
title_full_unstemmed Blue light regenerates functional visual pigments in mammals through a retinyl-phospholipid intermediate
title_sort blue light regenerates functional visual pigments in mammals through a retinyl-phospholipid intermediate
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2017-05-01
description It is currently thought that visual pigments in vertebrate photoreceptors are regenerated exclusively through enzymatic cycles. Here the authors show that mammalian photoreceptors also regenerate opsin pigments in light through photoisomerization of N-ret-PE (N-retinylidene-phosphatidylethanolamine.
url https://doi.org/10.1038/s41467-017-00018-4
work_keys_str_mv AT joannajkaylor bluelightregeneratesfunctionalvisualpigmentsinmammalsthrougharetinylphospholipidintermediate
AT tongzhouxu bluelightregeneratesfunctionalvisualpigmentsinmammalsthrougharetinylphospholipidintermediate
AT noriannetingram bluelightregeneratesfunctionalvisualpigmentsinmammalsthrougharetinylphospholipidintermediate
AT aviantsan bluelightregeneratesfunctionalvisualpigmentsinmammalsthrougharetinylphospholipidintermediate
AT haykhakobyan bluelightregeneratesfunctionalvisualpigmentsinmammalsthrougharetinylphospholipidintermediate
AT gordonlfain bluelightregeneratesfunctionalvisualpigmentsinmammalsthrougharetinylphospholipidintermediate
AT gabrielhtravis bluelightregeneratesfunctionalvisualpigmentsinmammalsthrougharetinylphospholipidintermediate
_version_ 1724317177718243328

Similar Items