Influenza H5N1 Virus of Birds Surrounding H5N1 Human Cases Have Specific Characteristics on the Matrix Protein
The H5N1 influenza virus in Indonesia has caused more than 100 people died due to the virus infections. Cases in humans were mostly due to the virus spread from the infected birds. This study characterized molecularly the H5N1 virus from birds around the H5N1 infection cases in humans in Indonesia....
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Bogor Agricultural University
2011-06-01
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doaj-162d8134e36141dea01b68f5352f42ff2020-11-24T21:42:46ZengBogor Agricultural UniversityHayati Journal of Biosciences1978-30192011-06-01182829010.4308/hjb.18.2.82Influenza H5N1 Virus of Birds Surrounding H5N1 Human Cases Have Specific Characteristics on the Matrix ProteinNI LUH PUTU INDI DHARMAYANTI0FERA IBRAHIM1DARMINTO2AMIN SOEBANDRIO3Indonesian Research Center for Veterinary Science, Jalan RE Martadinata 30, Bogor 16114, IndonesiaIndonesian Research Center for Veterinary Science, Jalan RE Martadinata 30, Bogor 16114, IndonesiaIndonesian Research Center for Veterinary Science, Jalan RE Martadinata 30, Bogor 16114, IndonesiaMicrobiology Department, Medicine Faculty, Universitas Indonesia, Jalan Salemba Raya No. 6, Jakarta 10430, IndonesiaThe H5N1 influenza virus in Indonesia has caused more than 100 people died due to the virus infections. Cases in humans were mostly due to the virus spread from the infected birds. This study characterized molecularly the H5N1 virus from birds around the H5N1 infection cases in humans in Indonesia. Result from this study revealed that in several cases, waterfowl species could become the source of H5N1 infections in human. We found that the one of six viruses used in this study probably was a first antigenic shift virus in Indonesia. This study shows that the AI viruses isolated from birds around humans infected by H5N1 virus has specific characteristics namely the presence of several amino acid substitutions especially on the M1 and M2 proteins. The substitutions are similar in most of H5N1 human cases in Indonesia.http://www.sciencedirect.com/science/article/pii/S1978301916301632molecular characterH5N1 virusbirdssurroundinghuman H5N1 infection |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
NI LUH PUTU INDI DHARMAYANTI FERA IBRAHIM DARMINTO AMIN SOEBANDRIO |
spellingShingle |
NI LUH PUTU INDI DHARMAYANTI FERA IBRAHIM DARMINTO AMIN SOEBANDRIO Influenza H5N1 Virus of Birds Surrounding H5N1 Human Cases Have Specific Characteristics on the Matrix Protein Hayati Journal of Biosciences molecular character H5N1 virus birds surrounding human H5N1 infection |
author_facet |
NI LUH PUTU INDI DHARMAYANTI FERA IBRAHIM DARMINTO AMIN SOEBANDRIO |
author_sort |
NI LUH PUTU INDI DHARMAYANTI |
title |
Influenza H5N1 Virus of Birds Surrounding H5N1 Human Cases Have Specific Characteristics on the Matrix Protein |
title_short |
Influenza H5N1 Virus of Birds Surrounding H5N1 Human Cases Have Specific Characteristics on the Matrix Protein |
title_full |
Influenza H5N1 Virus of Birds Surrounding H5N1 Human Cases Have Specific Characteristics on the Matrix Protein |
title_fullStr |
Influenza H5N1 Virus of Birds Surrounding H5N1 Human Cases Have Specific Characteristics on the Matrix Protein |
title_full_unstemmed |
Influenza H5N1 Virus of Birds Surrounding H5N1 Human Cases Have Specific Characteristics on the Matrix Protein |
title_sort |
influenza h5n1 virus of birds surrounding h5n1 human cases have specific characteristics on the matrix protein |
publisher |
Bogor Agricultural University |
series |
Hayati Journal of Biosciences |
issn |
1978-3019 |
publishDate |
2011-06-01 |
description |
The H5N1 influenza virus in Indonesia has caused more than 100 people died due to the virus infections. Cases in humans were mostly due to the virus spread from the infected birds. This study characterized molecularly the H5N1 virus from birds around the H5N1 infection cases in humans in Indonesia. Result from this study revealed that in several cases, waterfowl species could become the source of H5N1 infections in human. We found that the one of six viruses used in this study probably was a first antigenic shift virus in Indonesia. This study shows that the AI viruses isolated from birds around humans infected by H5N1 virus has specific characteristics namely the presence of several amino acid substitutions especially on the M1 and M2 proteins. The substitutions are similar in most of H5N1 human cases in Indonesia. |
topic |
molecular character H5N1 virus birds surrounding human H5N1 infection |
url |
http://www.sciencedirect.com/science/article/pii/S1978301916301632 |
work_keys_str_mv |
AT niluhputuindidharmayanti influenzah5n1virusofbirdssurroundingh5n1humancaseshavespecificcharacteristicsonthematrixprotein AT feraibrahim influenzah5n1virusofbirdssurroundingh5n1humancaseshavespecificcharacteristicsonthematrixprotein AT darminto influenzah5n1virusofbirdssurroundingh5n1humancaseshavespecificcharacteristicsonthematrixprotein AT aminsoebandrio influenzah5n1virusofbirdssurroundingh5n1humancaseshavespecificcharacteristicsonthematrixprotein |
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