Endosomal NOX2 oxidase exacerbates virus pathogenicity and is a target for antiviral therapy
Production of reactive oxygen species is an ancient antimicrobial mechanism, but its role in antiviral defense in mammals is unclear. Here, To et al. show that virus infection activates endosomal NOX2 oxidase and restricts TLR7 signaling, and that an endosomal NOX2 inhibitor decreases viral pathogen...
Main Authors: | Eunice E. To, Ross Vlahos, Raymond Luong, Michelle L. Halls, Patrick C. Reading, Paul T. King, Christopher Chan, Grant R. Drummond, Christopher G. Sobey, Brad R. S. Broughton, Malcolm R. Starkey, Renee van der Sluis, Sharon R. Lewin, Steven Bozinovski, Luke A. J. O’Neill, Tim Quach, Christopher J. H. Porter, Doug A. Brooks, John J. O’Leary, Stavros Selemidis |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2017-07-01
|
Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-017-00057-x |
Similar Items
-
Nox1 oxidase suppresses influenza a virus-induced lung inflammation and oxidative stress.
by: Stavros Selemidis, et al.
Published: (2013-01-01) -
Inhibition of Nox2 oxidase activity ameliorates influenza A virus-induced lung inflammation.
by: Ross Vlahos, et al.
Published: (2011-02-01) -
NOX2β: A novel splice variant of NOX2 that regulates NADPH oxidase activity in macrophages.
by: Craig B Harrison, et al.
Published: (2012-01-01) -
Resolving Viral-Induced Secondary Bacterial Infection in COPD: A Concise Review
by: Hao Wang, et al.
Published: (2018-10-01) -
Nox2 oxidase activity accounts for the oxidative stress and vasomotor dysfunction in mouse cerebral arteries following ischemic stroke.
by: T Michael De Silva, et al.
Published: (2011-01-01)