Identification of an ortholog of the eukaryotic RNA polymerase III subunit RPC34 in Crenarchaeota and Thaumarchaeota suggests specialization of RNA polymerases for coding and non-coding RNAs in Archaea
<p>Abstract</p> <p>One of the hallmarks of eukaryotic information processing is the co-existence of 3 distinct, multi-subunit RNA polymerase complexes that are dedicated to the transcription of specific classes of coding or non-coding RNAs. Archaea encode only one RNA polymerase th...
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doaj-163ba87f35ef445887a0df8b33191e722020-11-25T01:33:48ZengBMCBiology Direct1745-61502009-10-01413910.1186/1745-6150-4-39Identification of an ortholog of the eukaryotic RNA polymerase III subunit RPC34 in Crenarchaeota and Thaumarchaeota suggests specialization of RNA polymerases for coding and non-coding RNAs in ArchaeaSiebers BettinaMarrero JeannetteMakarova Kira SBlombach FabianKoonin Eugene VOost John<p>Abstract</p> <p>One of the hallmarks of eukaryotic information processing is the co-existence of 3 distinct, multi-subunit RNA polymerase complexes that are dedicated to the transcription of specific classes of coding or non-coding RNAs. Archaea encode only one RNA polymerase that resembles the eukaryotic RNA polymerase II with respect to the subunit composition. Here we identify archaeal orthologs of the eukaryotic RNA polymerase III subunit RPC34. Genome context analysis supports a function of this archaeal protein in the transcription of non-coding RNAs. These findings suggest that functional separation of RNA polymerases for protein-coding genes and non-coding RNAs might predate the origin of the Eukaryotes.</p> <p>Reviewers: This article was reviewed by Andrei Osterman and Patrick Forterre (nominated by Purificación López-García)</p> http://www.biology-direct.com/content/4/1/39 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Siebers Bettina Marrero Jeannette Makarova Kira S Blombach Fabian Koonin Eugene V Oost John |
spellingShingle |
Siebers Bettina Marrero Jeannette Makarova Kira S Blombach Fabian Koonin Eugene V Oost John Identification of an ortholog of the eukaryotic RNA polymerase III subunit RPC34 in Crenarchaeota and Thaumarchaeota suggests specialization of RNA polymerases for coding and non-coding RNAs in Archaea Biology Direct |
author_facet |
Siebers Bettina Marrero Jeannette Makarova Kira S Blombach Fabian Koonin Eugene V Oost John |
author_sort |
Siebers Bettina |
title |
Identification of an ortholog of the eukaryotic RNA polymerase III subunit RPC34 in Crenarchaeota and Thaumarchaeota suggests specialization of RNA polymerases for coding and non-coding RNAs in Archaea |
title_short |
Identification of an ortholog of the eukaryotic RNA polymerase III subunit RPC34 in Crenarchaeota and Thaumarchaeota suggests specialization of RNA polymerases for coding and non-coding RNAs in Archaea |
title_full |
Identification of an ortholog of the eukaryotic RNA polymerase III subunit RPC34 in Crenarchaeota and Thaumarchaeota suggests specialization of RNA polymerases for coding and non-coding RNAs in Archaea |
title_fullStr |
Identification of an ortholog of the eukaryotic RNA polymerase III subunit RPC34 in Crenarchaeota and Thaumarchaeota suggests specialization of RNA polymerases for coding and non-coding RNAs in Archaea |
title_full_unstemmed |
Identification of an ortholog of the eukaryotic RNA polymerase III subunit RPC34 in Crenarchaeota and Thaumarchaeota suggests specialization of RNA polymerases for coding and non-coding RNAs in Archaea |
title_sort |
identification of an ortholog of the eukaryotic rna polymerase iii subunit rpc34 in crenarchaeota and thaumarchaeota suggests specialization of rna polymerases for coding and non-coding rnas in archaea |
publisher |
BMC |
series |
Biology Direct |
issn |
1745-6150 |
publishDate |
2009-10-01 |
description |
<p>Abstract</p> <p>One of the hallmarks of eukaryotic information processing is the co-existence of 3 distinct, multi-subunit RNA polymerase complexes that are dedicated to the transcription of specific classes of coding or non-coding RNAs. Archaea encode only one RNA polymerase that resembles the eukaryotic RNA polymerase II with respect to the subunit composition. Here we identify archaeal orthologs of the eukaryotic RNA polymerase III subunit RPC34. Genome context analysis supports a function of this archaeal protein in the transcription of non-coding RNAs. These findings suggest that functional separation of RNA polymerases for protein-coding genes and non-coding RNAs might predate the origin of the Eukaryotes.</p> <p>Reviewers: This article was reviewed by Andrei Osterman and Patrick Forterre (nominated by Purificación López-García)</p> |
url |
http://www.biology-direct.com/content/4/1/39 |
work_keys_str_mv |
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